Publications related to Leveraging chromatin modules to explore the impact of regulatory variation on disease

Related publications (12)

Genome-to-genome analysis reveals associations between human and mycobacterial genetic variation in tuberculosis patients from Tanzania

Simon Sie-Mon Tang, Jacques Fellay, Zhi Ming Xu, Dylan Lawless, Olivier Noël Marie Naret, Sina Rüeger

The risk and prognosis of tuberculosis (TB) are influenced by a complex interplay between human and bacterial genetic factors. While previous genomic studies have largely examined human and bacterial genomes separately, we adopted an integrated approach to ...

Springer Science and Business Media LLC2025

Isocitrate dehydrogenase 1 primes group-3 medulloblastomas for cuproptosis

Sebastian Martin Waszak

MYC-driven group-3 medulloblastomas (MBs) are malignant pediatric brain cancers without cures. To define actionable metabolic dependencies, we identify upregulation of dihydrolipoyl transacetylase (DLAT), the E2-subunit of pyruvate dehydrogenase complex (P ...

Elsevier BV2025

Cell-autonomous timing drives the vertebrate segmentation clock's wave pattern

Andrew Charles Oates, Sundar Ram Naganathan, Daniele Soroldoni, Laurel Ann Rohde, Petr Strnad, Arianne Bercowsky Rama, Guillaume Michel Valentin

Rhythmic and sequential segmentation of the growing vertebrate body relies on the segmentation clock, a multi-cellular oscillating genetic network. The clock is visible as tissue-level kinematic waves of gene expression that travel through the presomitic m ...

2024

Pioneer factors: Emerging rules of engagement for transcription factors on chromatinized DNA

Manuel Carminati

Pioneering transcription factors (TFs) can drive cell fate changes by binding their DNA motifs in a repressive chromatin environment. Recent structures illustrate emerging rules for nucleosome engagement: TFs distort the nucleosomal DNA to gain access or e ...

CURRENT BIOLOGY LTD2024

Genome-scale models of metabolism and expression predict the metabolic burden of recombinant protein expression

Vassily Hatzimanikatis, Mohammadomid Oftadeh

The production of recombinant proteins in a host using synthetic constructs such as plasmids comes at the cost of detrimental effects such as reduced growth, energetic inefficiencies, and other stress responses, collectively known as metabolic burden. Incr ...

2024

Keap It in the Family: How to Fish out New Paradigms in Keap1-Mediated Cell Signaling

Yimon Aye, Kuan-Ting Huang

Keap1 is associated with cytoprotective signaling. These roles of Keap1 typically focus on its role as a degrader of the antioxidant response (AR) transcription factor, Nrf2, and the inhibition of this process upon Keap1 labeling by electrophiles. However, ...

Wiley-V C H Verlag Gmbh2023

On biochemical constructors and synthetic cells

Sebastian Maerkl

Is it possible to build life? More specifically, is it possible to create a living synthetic cell from inanimate building blocks? This question precipitated into one of the most significant grand challenges in biochemistry and synthetic biology, with sever ...

ROYAL SOC2023

Epigenetic silencing of selected hypothalamic neuropeptides in narcolepsy with cataplexy

Christian Iseli, Andrea Agnoletto

Narcolepsy with cataplexy is a sleep disorder caused by deficiency in the hypothalamic neuropeptide hypocretin/orexin (HCRT), unanimously believed to result from autoimmune destruction of hypocretin-producing neurons. HCRT deficiency can also occur in seco ...

National Academy of Sciences2023

Structure and dynamics of Toll immunoreceptor activation in the mosquito Aedes aegypti

Maria Josefina Marcaida Lopez

Aedes aegypti can act as a vector for viral pathogens but the mechanism of viral resistance and evolving host-pathogen tolerance are poorly understood. Here the authors structurally characterise a duplicated pair of interacting Toll immunoreceptors and the ...

Nature Research2022

Modulating dynamics and function of nuclear actin with synthetic bicyclic peptides

Davide Bertoldo, Raphael Johannes Gübeli

Actin exists in monomeric globular (G-) and polymerized filamentous (F-) forms and the dynamics of its polymerization/depolymerization are tightly regulated in both the cytoplasm and the nucleus. Various essential functions of nuclear actin have been ident ...

OXFORD UNIV PRESS2021

Manufacture of Recombinant Therapeutic Proteins Using Chinese Hamster Ovary Cells in Large-Scale Bioreactors History, Methods, and Perspectives

Florian Maria Wurm

In the last three decades, protein yields from recombinant CHO cells in bioreactors have increased 10-100 fold, as the result of improvements in media, bioprocess design and cell culture process control. The contribution of expression vector constructs and ...

Wiley2016

From functional genomics to systems (micro)biology

Stewart Cole

2009