Publications related to Gene-expression memory-based prediction of cell lineages from scRNA-seq datasets

Related publications (10)

Androgen Receptor Signaling in in vivo models of Estrogen Receptor-positive Breast Cancer and Normal Breast Epithelium

Steroid hormone receptors (HRs) are ligand-activated transcription factors that play a pivotal role in breast development and carcinogenesis. It is well established that estrogen receptor (ER) signaling is a major proliferative driver in estrogen receptor ...

EPFL2024

A live-cell image-based machine learning strategy for reducing variability in PSC differentiation systems

Salome Riccarda Püntener

The differentiation of pluripotent stem cells (PSCs) into diverse functional cell types provides a promising solution to support drug discovery, disease modeling, and regenerative medicine. However, functional cell differentiation is currently limited by t ...

SPRINGERNATURE2023

A Novel Approach in Edge Computing: In-Memory Sensing of Cancer Markers

David Heim, Sandro Carrara, Gian Luca Barbruni

We present here the first ever-reported direct computation of the cancer risk on cancer markers simultaneously detected by memristors. The novel approach in cancer diagnostics here proposed is based on the fusion of the three actions of sensing, computing ...

IEEE2022

Discussion on "Causal mediation of semicompeting risks" by Yen-Tsung Huang

Mats Julius Stensrud

2021

Disturbed mitochondrial dynamics in CD8(+)TILs reinforce T cell exhaustion

Li Tang, George Coukos, Nicola Vannini, Marcela Rincón-Restrepo, Min Gao

Ho and colleagues report that mitochondrial dysfunction and impaired mitophagy triggered by the tumor microenvironment lead to subsequent epigenetic changes and cause permanent T cell exhaustion and dysfunction. The metabolic challenges present in tumors a ...

2020

A bioluminescent probe for longitudinal monitoring of mitochondrial membrane potential

Elena Goun, Riccardo Sinisi, Arkadiy Bazhin, Tamara Maric, Ghyslain Martial Alain Budin

Mitochondrial membrane potential (Delta Psi(m)) is a universal selective indicator of mitochondrial function and is known to play a central role in many human pathologies, such as diabetes mellitus, cancer and Alzheimer's and Parkinson's diseases. Here, we ...

NATURE RESEARCH2020

CD36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors

Etienne Meylan

Depleting regulatory T cells (T-reg cells) to counteract immunosuppressive features of the tumor microenvironment (TME) is an attractive strategy for cancer treatment; however, autoimmunity due to systemic impairment of their suppressive function limits it ...

NATURE PUBLISHING GROUP2020

Temperature impacts human epidermal stem cell behaviour through thermoTRPs and mTOR signalling

Johannes Alexander Mosig

Adult stem cells are characterized by their unique ability to self-renew and give rise to a progeny of specialized/differentiated cells. Therefore, they have a remarkable potential for regenerative medicine. However, the use of adult stem cells is restrain ...

EPFL2013

Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self-Renewal during Homeostasis and Repair

Sandra Eloise Kjeldsen, Cyrille Dunant

Bone marrow hematopoietic stem cells (HSCs) are crucial to maintain lifelong production of all blood cells. Although HSCs divide infrequently, it is thought that the entire HSC pool turns over every few weeks, suggesting that HSCs regularly enter and exit ...

2008

Endocrine Disruptors and Breast Cancer

Cathrin Brisken

Breast cancer strikes one out of eight women in Switzerland. The increase in breast cancer incidence over the past 70 years parallels an enormous increase of man-made, persistent chemicals in our environment; some of which have endocrine-disrupting propert ...

2008