Publications related to Manufacture of Recombinant Therapeutic Proteins Using Chinese Hamster Ovary Cells in Large-Scale Bioreactors History, Methods, and Perspectives

Related publications (8)

Leveraging chromatin modules to explore the impact of regulatory variation on disease

Human genome is complex and hierarchically organized within the nucleus, where cis-regulatory elements (CREs) frequently interact within topologically associated domains to regulate gene expression. While genomic technologies and computational approaches h ...

EPFL2025

Regional differences in progenitor metabolism shape brain growth during development

Davide D'Amico, Andréane Mégane Fouassier

Mammals have particularly large forebrains compared with other brain parts, yet the developmental mechanisms underlying this regional expansion remain poorly understood. Here, we provide a single-cell-resolution birthdate atlas of the mouse brain (www.neur ...

2025

Genome-scale models of metabolism and expression predict the metabolic burden of recombinant protein expression

Vassily Hatzimanikatis, Mohammadomid Oftadeh

The production of recombinant proteins in a host using synthetic constructs such as plasmids comes at the cost of detrimental effects such as reduced growth, energetic inefficiencies, and other stress responses, collectively known as metabolic burden. Incr ...

2024

Cell-autonomous timing drives the vertebrate segmentation clock's wave pattern

Andrew Charles Oates, Sundar Ram Naganathan, Daniele Soroldoni, Laurel Ann Rohde, Petr Strnad, Arianne Bercowsky Rama, Guillaume Michel Valentin

Rhythmic and sequential segmentation of the growing vertebrate body relies on the segmentation clock, a multi-cellular oscillating genetic network. The clock is visible as tissue-level kinematic waves of gene expression that travel through the presomitic m ...

2024

An Injectable Family Of Soft Tissue Hydrogel Adhesives For Knee Applications

Dominique Pioletti, Christophe Moser, Pierre-Etienne Bourban, Peyman Karami, Céline Samira Wyss

MARY ANN LIEBERT, INC2022

Structure and dynamics of Toll immunoreceptor activation in the mosquito Aedes aegypti

Maria Josefina Marcaida Lopez

Aedes aegypti can act as a vector for viral pathogens but the mechanism of viral resistance and evolving host-pathogen tolerance are poorly understood. Here the authors structurally characterise a duplicated pair of interacting Toll immunoreceptors and the ...

Nature Research2022

An amplitude equation modelling the double-crest swirling in orbital-shaken cylindrical containers

François Gallaire, Alessandro Bongarzone, Margherita Guido

Container motion along a planar circular trajectory at a constant angular velocity, i.e. orbital shaking, is of interest in several industrial applications, e.g. for fermentation processes or in cultivation of stem cells, where good mixing and efficient ga ...

Cambridge University Press2022

Polyethylenimine-based quality control assay for plasmid DNA

Florian Maria Wurm, David Hacker, Martin Jordan, Martin Bertschinger, Gaurav Backliwal

2006