Publication

Mechanisms of force generation and transmission by myofibroblasts

2003
Journal Articles

Abstract

The myofibroblast has been shown to have a key role in tissue reconstruction after injury and pathological changes characterized by fibrosis. Force generation by the myofibroblast depends on the isometric contraction of stress fibers containing alpha-smooth muscle actin, and is mediated through Rho/Rho-kinase. The force is transmitted by vinculin and tensin-containing "supermature" focal adhesions, which connect stress fibers with the extracellular matrix. Force production and transmission by the myofibroblast are modulated by the coordinated action of cytokines, extracellular matrix components and mechanical tension. Regulation of these phenomena will be important for therapeutic strategies aimed at influencing fibrocontractive diseases.

Official source

https://infoscience.epfl.ch/entities/publication/c3ec1dd1-80fd-438d-857a-e4b475bb1200

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2003
Journal Articles

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/c3ec1dd1-80fd-438d-857a-e4b475bb1200

About this result

Related concepts (32)

Extracellular matrix

In biology, the extracellular matrix (ECM), also called intercellular matrix, is a network consisting of extracellular macromolecules and minerals, such as collagen, enzymes, glycoproteins and hydroxyapatite that provide structural and biochemical support to surrounding cells. Because multicellularity evolved independently in different multicellular lineages, the composition of ECM varies between multicellular structures; however, cell adhesion, cell-to-cell communication and differentiation are common functions of the ECM.

Optical fiber

An optical fiber, or optical fibre in Commonwealth English, is a flexible, transparent fiber made by drawing glass (silica) or plastic to a diameter slightly thicker than that of a human hair. Optical fibers are used most often as a means to transmit light between the two ends of the fiber and find wide usage in fiber-optic communications, where they permit transmission over longer distances and at higher bandwidths (data transfer rates) than electrical cables.

Polarization-maintaining optical fiber

In fiber optics, polarization-maintaining optical fiber (PMF or PM fiber) is a single-mode optical fiber in which linearly polarized light, if properly launched into the fiber, maintains a linear polarization during propagation, exiting the fiber in a specific linear polarization state; there is little or no cross-coupling of optical power between the two polarization modes. Such fiber is used in special applications where preserving polarization is essential.

Related publications (3)

Mechanisms of force generation and transmission by myofibroblasts

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