Publications related to Engineering nanomaterial surfaces for biomedical applications: antiviral surface coatings, antiviral nanoparticles and lipid-based biopharmaceutical drug systems

Related publications (14)

Membrane Potential Fluctuations and Water Asymmetry on Plasma Cell and Model Lipid Membranes: Origins, Implications and Properties

Nelson Alonso Correa Rojas, Lena Dalifoski, Sylvie Roke, Arianna Marchioro, Orly Bagunu Tarun, David Roesel, Maksim Eremchev, Seonwoo Lee, Mischa Samuel Flór, Bryan Zhi Li, Iwona Swiderska

Membrane potential fluctuations have previously been detected using second harmonic (SH) water imaging on neuronal cells and model lipid bilayer membranes. We report that such fluctuations are also visible when membrane potential-sensitive fluorophores are ...

ROYAL SOC CHEMISTRY2025

Hyperthermic Intrathoracic Chemotherapy Modulates the Immune Microenvironment of Pleural Mesothelioma and Improves the Impact of Dual Immune Checkpoint Inhibition

Paul Joseph Dyson, Aspasia Gkasti, Yameng Hao

Pleural mesothelioma is a fatal disease with limited treatment options. Recently, pleural mesothelioma management has improved with the development of immune checkpoint inhibitors (ICI). In first-line therapy, dual PD-1 and CTLA-4 blockade enhances tumor c ...

AMER ASSOC CANCER RESEARCH2025

Spatial and stoichiometric in situ analysis of biomolecular oligomerization at single-protein resolution

Maartje Martina Cornelia Bastings

Latest advances in super-resolution microscopy allow the study of subcellular features at the level of single proteins, which could lead to discoveries in fundamental biological processes, specifically in cell signaling mediated by membrane receptors. Desp ...

Springer Science and Business Media LLC2025

Intelligent and Self-Driving Microscopy of Protein Aggregation in Neurodegenerative Diseases

Khalid Ashraf Mohie Ibrahim

Neurodegenerative diseases, such as Alzheimer's, Parkinson's, and Huntington's, afflict tens of millions of patients worldwide. They are characterized by protein aggregation and progressive neuronal loss, leading to cognitive and motor impairments, and ult ...

EPFL2025

Optical Control of Membrane Viscosity Modulates ER-to-Golgi Trafficking

Antonino Asaro

The lipid composition of cellular membranes is highly dynamic and undergoes continuous remodeling, affecting the biophysical properties critical to biological function. Here, we introduce an optical approach to manipulate membrane viscosity based on an exo ...

American Chemical Society (ACS)2025

Ca2+-dependent lipid preferences shape synaptotagmin-1 C2A and C2B dynamics: Insights from experiments and simulations

Lucas Sebastian Powell-Rudden

Signal transmission between neurons requires exocytosis of neurotransmitters from the lumen of synaptic vesicles into the synaptic cleft. Following an influx of Ca2+, this process is facilitated by the Ca2+ sensor synaptotagmin-1. The underlying mechanisms ...

CELL PRESS2024

Individual nanostructures in an epsilon-near-zero material probed with 3D-sculpted light

Lisa Jutta Ackermann

Epsilon-near-zero (ENZ) materials, i.e., materials with a vanishing real part of the permittivity, have become an increasingly desirable platform for exploring linear and nonlinear optical phenomena in nanophotonic and on-chip environments. ENZ materials i ...

Optica Publishing Group2024

Tuning Transduction from Hidden Observables to Optimize Information Harvesting

Giorgio Nicoletti

Biological and living organisms sense and process information from their surroundings, typically having access only to a subset of external observables for a limited amount of time. In this Letter, we uncover how biological systems can exploit these access ...

2024

Missense variants in CMS22 patients reveal that PREPL has both enzymatic and nonenzymatic functions

Matteo Dal Peraro, Maria Josefina Marcaida Lopez, Aleksandar Antanasijevic, Anastasia Theodoropoulou, Edoardo Cavani

Congenital myasthenic syndrome-22 (CMS22, OMIM 616224) is a rare genetic disorder caused by deleterious genetic variation in the prolyl endopeptidase-like (PREPL) gene. Previous reports have described patients with deletions and nonsense variants in PREPL, ...

American Society for Clinical Investigation2024

Cryo-EM structures of ClC-2 chloride channel reveal the blocking mechanism of its specific inhibitor AK-42

Horst Arthur Vogel

ClC-2 transports chloride ions across plasma membranes and plays critical roles in cellular homeostasis. Its dysfunction is involved in diseases including leukodystrophy and primary aldosteronism. AK-42 was recently reported as a specific inhibitor of ClC- ...

Nature Portfolio2023

An anti-influenza combined therapy assessed by single cell RNA-sequencing

Francesco Stellacci

Influenza makes millions of people ill every year, placing a large burden on the healthcare system and the economy. To develop a treatment against influenza, we combined virucidal sialylated cyclodextrins with interferon lambda and demonstrated, in human a ...

NATURE PORTFOLIO2022

Molecular Stabilization of Sub-Nanometer Cu Clusters for Selective CO2 Electromethanation

Jun Li

Electrochemical CO2 methanation powered by renewable electricity provides a promising approach to utilizing CO2 in the form of a high-energy-density, clean fuel. Cu nanoclusters have been predicted by theoretical calculations to improve methane selectivity ...

WILEY-V C H VERLAG GMBH2022

A Resonant Graphene NEMS Vibrometer

Luis Guillermo Villanueva Torrijo, Daniel Moreno Garcia

Measuring vibrations is essential to ensuring building structural safety and machine stability. Predictive maintenance is a central internet of things (IoT) application within the new industrial revolution, where sustainability and performance increase ove ...

WILEY-V C H VERLAG GMBH2022

Unsymmetrical Trifluoromethyl Methoxyphenyl beta-Diketones: Effect of the Position of Methoxy Group and Coordination at Cu(II) on Biological Activity

Euro Solari

Copper(II) complexes with 1,1,1-trifluoro-4-(4-methoxyphenyl)butan-2,4-dione (HL1) were synthesized and characterized by elemental analysis, FT-IR spectroscopy, and single crystal X-ray diffraction. The biological properties of HL1 and cis-[Cu(L1)(2)(DMSO) ...

MDPI2021