Publication

PEG-based hydrogels for blocking, presenting and receiving information in the control of wound healing

1997
Journal Articles

Abstract

A review with 6 refs. of the use of adherent polymer hydrogels to prevent attachment of platelets to artery walls. Adhesion peptides incorporated in these hydrogels may further inhibit thrombogenesis and addnl. promote reendothelialization. Hydrogels with backbone protease-sensitive sites may be eroded by tissue proteases and thus promote remodeling during wound healing. [on SciFinder (R)]

Official source

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1997
Journal Articles

Abstract

Official source

Related concepts (22)

Wound healing

Wound healing refers to a living organism's replacement of destroyed or damaged tissue by newly produced tissue. In undamaged skin, the epidermis (surface, epithelial layer) and dermis (deeper, connective layer) form a protective barrier against the external environment. When the barrier is broken, a regulated sequence of biochemical events is set into motion to repair the damage. This process is divided into predictable phases: blood clotting (hemostasis), inflammation, tissue growth (cell proliferation), and tissue remodeling (maturation and cell differentiation).

Healing

With physical trauma or disease suffered by an organism, healing involves the repairing of damaged tissue(s), organs and the biological system as a whole and resumption of (normal) functioning. Medicine includes the process by which the cells in the body regenerate and repair to reduce the size of a damaged or necrotic area and replace it with new living tissue. The replacement can happen in two ways: by regeneration in which the necrotic cells are replaced by new cells that form "like" tissue as was originally there; or by repair in which injured tissue is replaced with scar tissue.

Chronic wound

A chronic wound is a wound that does not heal in an orderly set of stages and in a predictable amount of time the way most wounds do; wounds that do not heal within three months are often considered chronic. Chronic wounds seem to be detained in one or more of the phases of wound healing. For example, chronic wounds often remain in the inflammatory stage for too long. To overcome that stage and jump-start the healing process, a number of factors need to be addressed such as bacterial burden, necrotic tissue, and moisture balance of the whole wound.