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The fission yeast septation initiation network, or SIN, is a signal transduction network that is required for septum formation in Schizosaccharomyces pombe. Its activity is tightly regulated through the cell cycle, to ensure proper co-ordination of mitosis and cytokinesis. SIN signalling requires three protein kinases for its function and is mediated by a ras-superfamily GTPase. We discuss the elements of the SIN and how they are regulated.
Viesturs Simanis, Andrea Krapp, Bastien Mangeat, Özge Uysal Özdemir
Viesturs Simanis, Andrea Krapp, Bastien Mangeat, Özge Uysal Özdemir