Publication

Mycobacterium leprae genotype amplified from an archaeological case of lepromatous leprosy in Central Asia

Stewart Cole
2009
Journal Articles

Abstract

We have amplified Mycobacterium leprae DNA from the skeleton of an adult human female exhibiting signs of lepromatous leprosy (LL). The remains were excavated from the site of Devkesken 6 on the Ustyurt plateau of Uzbekistan and date to between the 1st and 4th centuries AD. Recovered DNA was fragmented but of sufficient quality and quantity to allow a series of biomolecular genotyping methods to be applied. These methods included variable nucleotide tandem repeat (VNTR) typing of two microsatellite and one minisatellite regions and also single-nucleotide polymorphism (SNP) typing for nine informative loci.

Official source

https://infoscience.epfl.ch/entities/publication/bd89b5f0-3a97-4547-8a67-dfac67364500

About this result

This page is automatically generated and may contain information that is not correct, complete, up-to-date, or relevant to your search query. The same applies to every other page on this website. Please make sure to verify the information with EPFL's official sources.

Graph Chat

Chat with Graph Search

Ask any question about EPFL courses, lectures, exercises, research, news, etc. or try the example questions below.

DISCLAIMER: The Graph Chatbot is not programmed to provide explicit or categorical answers to your questions. Rather, it transforms your questions into API requests that are distributed across the various IT services officially administered by EPFL. Its purpose is solely to collect and recommend relevant references to content that you can explore to help you answer your questions.

Stewart Cole
2009
Journal Articles

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/bd89b5f0-3a97-4547-8a67-dfac67364500

About this result

Related concepts (30)

Archaeological site

An archaeological site is a place (or group of physical sites) in which evidence of past activity is preserved (either prehistoric or historic or contemporary), and which has been, or may be, investigated using the discipline of archaeology and represents a part of the archaeological record. Sites may range from those with few or no remains visible above ground, to buildings and other structures still in use. Beyond this, the definition and geographical extent of a "site" can vary widely, depending on the period studied and the theoretical approach of the archaeologist.

Archaeology

Archaeology or archeology is the study of human activity through the recovery and analysis of material culture. The archaeological record consists of artifacts, architecture, biofacts or ecofacts, sites, and cultural landscapes. Archaeology can be considered both a social science and a branch of the humanities. It is usually considered an independent academic discipline, but may also be classified as part of anthropology (in North America – the four-field approach), history or geography.

Archaeological excavation

In archaeology, excavation is the exposure, processing and recording of archaeological remains. An excavation site or "dig" is the area being studied. These locations range from one to several areas at a time during a project and can be conducted over a few weeks to several years. Excavation involves the recovery of several types of data from a site.

Related publications (28)

Mycobacterium leprae genotype amplified from an archaeological case of lepromatous leprosy in Central Asia

Chat with Graph Search

Investigating the composition and recruitment of the mycobacterial ImuA'-ImuB-DnaE2 mutasome

Development and validation of a multiplex real-time qPCR assay using GMP-grade reagents for leprosy diagnosis

Stabilization of cultural innovations depends on population density: Testing an epidemiological model of cultural evolution against a global dataset of rock art sites and climate-based estimates of ancient population densities