Publication

Rat model: neural substrates of the battered woman syndrome

2010
Student Projects

Abstract

This study is part of a long term study on a male rat model of peripubertal stress in the Laboratory of Behavioural Genetics that shows increase aggressive behaviours against their partners. We are using here these rats in order to create a female rat model victim of Intimate Partner Violence during pregnancy and to study the generalisation of fear to all male, that is a symptom of this type of aggression, through behavioural analysis, serotonergic cell activation of the Dorsal Raphe Nucleus (DRN) and activation of other regions known to interact with the DRN such as Periaqueductal Gray (PAG) and Amygdala. This study also reveal an in-utero transmission of aggressive behaviours to the offspring of peripubertally stressed male. Our findings suggest that our model show a generalisation of fear that depends on the type of aggression experienced. This generalisation is mediated by an increase of activation of serotonergic cells of the DRN as well as a general disruption of pattern of activation at the basal level. Interestingly, our results do not show a clear direct link between activation of DRN, PAG and Amygdala during generalisation of fear

Official source

https://infoscience.epfl.ch/entities/publication/bcdc642e-e457-4cc1-a25a-479b9cc4c996

About this result

This page is automatically generated and may contain information that is not correct, complete, up-to-date, or relevant to your search query. The same applies to every other page on this website. Please make sure to verify the information with EPFL's official sources.

Graph Chat

Chat with Graph Search

Ask any question about EPFL courses, lectures, exercises, research, news, etc. or try the example questions below.

DISCLAIMER: The Graph Chatbot is not programmed to provide explicit or categorical answers to your questions. Rather, it transforms your questions into API requests that are distributed across the various IT services officially administered by EPFL. Its purpose is solely to collect and recommend relevant references to content that you can explore to help you answer your questions.

2010
Student Projects

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/bcdc642e-e457-4cc1-a25a-479b9cc4c996

About this result

Related concepts (32)

Aggression

Aggression is hostile and antagonistic behavior, often with the intent to cause harm, although it can be channeled into creative and practical outlets for some. It may occur either reactively or without provocation. In humans, aggression can be caused by various triggers, from frustration due to blocked goals to feeling disrespected. Human aggression can be classified into direct and indirect aggression; whilst the former is characterized by physical or verbal behavior intended to cause harm to someone, the latter is characterized by behavior intended to harm the social relations of an individual or group.

Behaviour therapy

Behaviour therapy or behavioural psychotherapy is a broad term referring to clinical psychotherapy that uses techniques derived from behaviourism and/or cognitive psychology. It looks at specific, learned behaviours and how the environment, or other people's mental states, influences those behaviours, and consists of techniques based on behaviorism's theory of learning: respondent or operant conditioning. Behaviourists who practice these techniques are either behaviour analysts or cognitive-behavioural therapists.

Serotonin

Serotonin (ˌsɛrəˈtoʊnᵻn,_ˌsɪərə-) or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter. Its biological function is complex and multifaceted, modulating mood, cognition, reward, learning, memory, and numerous physiological processes such as vomiting and vasoconstriction. Approximately 90% of the serotonin the human body produces is in the gastrointestinal tract's enterochromaffin cells, where it regulates intestinal movements.