Publication

Mechanisms of spindle positioning: focus on flies and worms

2002
Journal Articles

Abstract

Accurate spindle positioning is crucial for spatial control of cell division. During metazoan development, coordination between polarity cues and spindle position also ensures correct segregation of cell fate determinants. Converging evidence indicates that spindle positioning is achieved through interactions between cortical anchors and the plus ends of microtubules, generating pulling forces acting on spindle poles. This article discusses recent findings that indicate how this mechanism might be used for spindle positioning during Drosophila and Caenorhabditis elegans development.

Official source

https://infoscience.epfl.ch/entities/publication/bbb4ea65-7335-4463-a76c-c74418112c49

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2002
Journal Articles

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/bbb4ea65-7335-4463-a76c-c74418112c49

About this result

Related concepts (32)

Asymmetric cell division

An asymmetric cell division produces two daughter cells with different cellular fates. This is in contrast to symmetric cell divisions which give rise to daughter cells of equivalent fates. Notably, stem cells divide asymmetrically to give rise to two distinct daughter cells: one copy of the original stem cell as well as a second daughter programmed to differentiate into a non-stem cell fate. (In times of growth or regeneration, stem cells can also divide symmetrically, to produce two identical copies of the original cell.

Cytokinesis

Cytokinesis (ˌsaɪtoʊkɪˈniːsɪs) is the part of the cell division process during which the cytoplasm of a single eukaryotic cell divides into two daughter cells. Cytoplasmic division begins during or after the late stages of nuclear division in mitosis and meiosis. During cytokinesis the spindle apparatus partitions and transports duplicated chromatids into the cytoplasm of the separating daughter cells. It thereby ensures that chromosome number and complement are maintained from one generation to the next and that, except in special cases, the daughter cells will be functional copies of the parent cell.

Spindle apparatus

In cell biology, the spindle apparatus is the cytoskeletal structure of eukaryotic cells that forms during cell division to separate sister chromatids between daughter cells. It is referred to as the mitotic spindle during mitosis, a process that produces genetically identical daughter cells, or the meiotic spindle during meiosis, a process that produces gametes with half the number of chromosomes of the parent cell. Besides chromosomes, the spindle apparatus is composed of hundreds of proteins.

Related publications (6)

Mechanisms of spindle positioning: focus on flies and worms

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Biophysical modeling of thalamic reticular nucleus subpopulations and their differential contribution to spindle dynamics

Development of a microfluidic on-chip reverse transcription module for the analysis of hematopoietic single stem cells

Control of Adult Stem Cell Function in Bioengineered in vitro Niches