Yeast Three-Hybrid Screening for Identifying Anti-Tuberculosis Drug Targets

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Macrocycles have excellent potential as therapeutics due to their ability to bind challenging targets. However, generating macrocycles against new targets is hindered by a lack of large macrocycle libraries for high-throughput screening. To overcome this, ...

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The emergence of Mycobacterium tuberculosis strains resistant to current first-line antibiotic regimens constitutes a major global health threat. New treatments against multidrug-resistant tuberculosis (MDR-TB) are thus eagerly needed in particular in coun ...

Tuberculosis (TB), whose etiological agent is Mycobacterium tuberculosis (M. tuberculosis), has plagued humanity since antiquity. Even with chemotherapy available today, TB is the leading cause of death due to an infectious disease. Modern day factors, suc ...

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Yeast Three-Hybrid Screening for Identifying Anti-Tuberculosis Drug Targets

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Generating macrocyclic inhibitors of protein-protein interactions

Synthesis and direct assay of large macrocycle diversities by combinatorial late-stage modification at picomole scale

De novo developed small cyclic peptides that are orally available

Methods for the generation of large combinatorial macrocycle libraries

Establishing a Ternary System for Optical Monitoring of DNA-Protein Interactions with Single-Walled Carbon Nanotubes

Generation of a Large Peptide Phage Display Library by Self-Ligation of Whole-Plasmid PCR Product

The functional proteome landscape of Escherichia coli

High-throughput microfluidic platforms for characterizing and engineering cell-free gene regulatory circuits

Integrated microfluidic tools for the characterization of protein/DNA interactions in vitro and in vivo

Design and validation of bioorthogonal probes for cellular disease models

Innovative Tools and in vivo Methods for Tuberculosis Drug Discovery and Development

An optimized and validated 384-well plate assay to test platelet function in a high-throughput screening format

Monitoring Tuberculosis Drug Activity in Live Animals by Using Near-Infrared Fluorescence Imaging

A novel cell-based sensor detecting the activity of individual basic proprotein convertases

Analytical Approaches for Monitoring DNA–Protein Interactions

Development and validation of a multiplex UHPLC-MS/MS method for the determination of the investigational antibiotic against multi-resistant tuberculosis macozinone (PBTZ169) and five active metabolites in human plasma

More Medicines for Tuberculosis: Fuelling Drug Discovery against Mycobacterium tuberculosis

Arylvinylpiperazine Amides, a New Class of Potent Inhibitors Targeting QcrB of Mycobacterium tuberculosis

Development of microfluidic tools and methods for the biochemical characterization of scFv and Cas9 affinity reagents and their applications in molecular detection

Microfluidic platforms for high-throughput mammalian cell printing, transfection, and dosage-dependent studies