Skeletal muscle enhancer interactions identify genes controlling whole-body metabolism

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Genetic variation plays a crucial role in human disease susceptibility and molecular pathophysiology. This thesis explores genetic determinants of disease using advanced computational approaches, including statistical modeling, network analysis, and deep l ...

The adaptation of organisms to their environment depends on the innovative potential inherent to genetic variation. In complex organisms such as mammals, processes like development and immunity require tight gene regulation. Complex forms emerge more often ...

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Growing evidence indicates that transposable elements (TEs) play important roles in evolution by providing genomes with coding and non-coding sequences. Identification of TE-derived functional elements, however, has relied on TE annotations in individual s ...

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Experimental measurements of the turbulence amplitude utilizing a short pulse reflectometry method are presented. Two discharges with shaped plasma possessing opposite signs of triangularity are considered and a higher turbulence amplitude is found in the ...

Among the inherited myopathies, a group of muscular disorders characterized by structural and metabolic impairments in skeletal muscle, Duchenne muscular dystrophy (DMD) stands out for its devastating progression. DMD pathogenesis is driven by the progress ...

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Skeletal muscle enhancer interactions identify genes controlling whole-body metabolism

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Learning the language of the genome: AI- and data-driven decoding of genetic variants and disease mechanisms

Meeting our Makers: Uncovering the cis-regulatory activity of transposable elements using statistical learning

The dynamic genetic determinants of increased transcriptional divergence in spermatids

Ancestral genome reconstruction enhances transposable element annotation by identifying degenerate integrants

Quantitative characterization of the inorganic phosphate gene regulatory networks in S. cerevisiae and bottom up engineering an orthogonal gene network

Single-cell epigenomic reconstruction of developmental trajectories from pluripotency in human neural organoid systems

Androgen Receptor Signaling in in vivo models of Estrogen Receptor-positive Breast Cancer and Normal Breast Epithelium

Evaluation of antigravitational support levels provided by a passive upper-limb occupational exoskeleton in repetitive arm movements

Validation of short-pulse reflectometry turbulence measurements with a synthetic diagnostic

Cyclo His-Pro Attenuates Muscle Degeneration in Murine Myopathy Models

Innovative Biomarkers for Obesity and Type 1 Diabetes Based on Bifidobacterium and Metabolomic Profiling

Decoding Chromatin Ubiquitylation: A Chemical Biology Perspective

Toward universal cell embeddings: integrating single-cell RNA-seq datasets across species with SATURN

The autism susceptibility kinase, TAOK2, phosphorylates eEF2 and modulates translation

Microtubule-mediated GLUT4 trafficking is disrupted in insulin-resistant skeletal muscle

Environment-dependent epistasis increases phenotypic diversity in gene regulatory networks

Anti-miR-873-5p improves alcohol-related liver disease by enhancing hepatic deacetylation via SIRT1

Deciphering the molecular events leading to the global restoration of the chromatin landscape during mitotic exit

Hippo-YAP/TAZ signalling coordinates adipose plasticity and energy balance by uncoupling leptin expression from fat mass

Modeling, analysis, and design of complex biological networks