Publication

Analysis and Design of Biological Circuits and Systems

2009
Conference Papers

Abstract

Systems and synthetic biology are two emerging disciplines that hold promise to revolutionize our understanding of biological systems and to herald a new era of programmable hardware, respectively. Mathematical abstraction and today's abundance of quantitative biological data enables the up-scaling of analysis and design methodologies. In this tutorial paper we provide an engineering-centered introduction to those disciplines. Biological key concepts such as the central dogma of molecular biology are discussed, descriptions of bio-molecular reaction networks in terms of continuous-time Markov processes and ordinary differential equations are reviewed. Topological analysis of networks is introduced and the methods of metabolic flux balance analysis and elementary flux modes or extreme pathways are discussed.

Official source

https://infoscience.epfl.ch/entities/publication/baa7aece-41c2-42d0-b144-ac8d6bc338d5

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2009
Conference Papers

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/baa7aece-41c2-42d0-b144-ac8d6bc338d5

About this result

Related concepts (32)

Metabolic network modelling

Metabolic network modelling, also known as metabolic network reconstruction or metabolic pathway analysis, allows for an in-depth insight into the molecular mechanisms of a particular organism. In particular, these models correlate the genome with molecular physiology. A reconstruction breaks down metabolic pathways (such as glycolysis and the citric acid cycle) into their respective reactions and enzymes, and analyzes them within the perspective of the entire network.

Systems biology

Systems biology is the computational and mathematical analysis and modeling of complex biological systems. It is a biology-based interdisciplinary field of study that focuses on complex interactions within biological systems, using a holistic approach (holism instead of the more traditional reductionism) to biological research. Particularly from the year 2000 onwards, the concept has been used widely in biology in a variety of contexts.

Synthetic biological circuit

Synthetic biological circuits are an application of synthetic biology where biological parts inside a cell are designed to perform logical functions mimicking those observed in electronic circuits. The applications range from simply inducing production to adding a measurable element, like GFP, to an existing natural biological circuit, to implementing completely new systems of many parts. The goal of synthetic biology is to generate an array of tunable and characterized parts, or modules, with which any desirable synthetic biological circuit can be easily designed and implemented.

Related publications (32)

Analysis and Design of Biological Circuits and Systems

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