Publication

Acoustic Resonators for Intracellular Tagging

2020
Student Projects

Abstract

Cell migration has always been essential for understanding the underlying mechanisms of physiological phenomena. For this reason, many diverse cell tracking methods are presented in literature, such as optical imaging, MRI and radionuclear imaging. However, optical methods are invasive and MRI and radionuclear imaging suffer from low spatial resolution. To overcome the limits imposed by state of the art cell tracking technologies, we propose to use plate acoustic wave resonators as a novel method for tagging single cells and tracking their spatio-temporal dynamics. In this work, we investigate and optimize the design of these tags, using finite element modelling simulations.

Official source

https://infoscience.epfl.ch/entities/publication/ba8b1bd8-f7ab-44d2-b754-5e9ff148a916

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2020
Student Projects

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/ba8b1bd8-f7ab-44d2-b754-5e9ff148a916

About this result

Related concepts (28)

Acoustic metamaterial

An acoustic metamaterial, sonic crystal, or phononic crystal is a material designed to control, direct, and manipulate sound waves or phonons in gases, liquids, and solids (crystal lattices). Sound wave control is accomplished through manipulating parameters such as the bulk modulus β, density ρ, and chirality. They can be engineered to either transmit, or trap and amplify sound waves at certain frequencies. In the latter case, the material is an acoustic resonator.

Resonator

A resonator is a device or system that exhibits resonance or resonant behavior. That is, it naturally oscillates with greater amplitude at some frequencies, called resonant frequencies, than at other frequencies. The oscillations in a resonator can be either electromagnetic or mechanical (including acoustic). Resonators are used to either generate waves of specific frequencies or to select specific frequencies from a signal. Musical instruments use acoustic resonators that produce sound waves of specific tones.

Tracking system

A tracking system, also known as a locating system, is used for the observing of persons or objects on the move and supplying a timely ordered sequence of location data for further processing. A myriad of tracking systems exists. Some are 'lag time' indicators, that is, the data is collected after an item has passed a point for example a bar code or choke point or gate. Others are 'real-time' or 'near real-time' like Global Positioning Systems (GPS) depending on how often the data is refreshed.

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