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Given a permutation group G , the derangement graph of G is defined with vertex set G , where two elements x and y are adjacent if and only if is a derangement. We establish that if G is transitive with degree exceeding 30, then the derangement graph of G contains a complete subgraph with four vertices. In the process, we determine all transitive groups whose derangement graph does not contain a complete subgraph on four vertices. As a consequence, if G is a normal subgroup of A such that and U is a subgroup of G satisfying , then . This provides support for a conjecture by Neumann and Praeger concerning Kronecker classes.