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To regenerate or not to regenerate: Vertebrate model organisms of regeneration-competency and -incompetency

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A Robotic Surgery Platform for Automated Tissue Micromanipulation in Zebrafish Embryos

Mahmut Selman Sakar, Andrew Charles Oates, Ece Özelçi, Laurel Ann Rohde

Microsurgical manipulations are key experimental techniques in life science research, particularly in embryology. These techniques are most often performed manually by highly skilled scientists, posing limitations on speed, precision, and reproducibility. ...

2024

Targeted search for scaling genes reveals matrix metalloproteinase 3 as a scaler of the dorsal-ventral pattern in Xenopus laevis embryos

Daria Korotkova

How embryos scale patterning according to size is still not fully understood. Through in silico screening and analysis of reaction-diffusion systems that could be responsible for scaling, we predicted the existence of genes whose expression is sensitive to ...

Cell Press - Elsevier2022

Approaches to Test the Neurotoxicity of Environmental Contaminants in the Zebrafish Model: From Behavior to Molecular Mechanisms

Sarah-Katharina Könemann

The occurrence of neuroactive chemicals in the aquatic environment is on the rise and poses a potential threat to aquatic biota of currently unpredictable outcome. In particular, subtle changes caused by these chemicals to an organism's sensation or behavi ...

2021

Multiple testing with test statistics following heavy-tailed distributions

Zhiwen Jiang

In multiple testing problems where the components come from a mixture model of noise and true effect, we seek to first test for the existence of the non-zero components, and then identify the true alternatives under a fixed significance level

\alpha

. Two ...

EPFL2021

The detection of two-component mixture alternatives : Theory and methods

Daria Rukina

In this thesis, we deal with one of the facets of the statistical detection problem. We study a particular type of alternative, the mixture model. We consider testing where the null hypothesis corresponds to the absence of a signal, represented by some kno ...

EPFL2018