Publication

Advancing Brain Morphometry at 7T: A Pilot Study on Epilepsy Patients

Jean-Philippe Thiran
2025

Abstract

Motivation: Unlock the full potential of ultra-high field MRI enabling the detection of subtle structural changes. Goal(s): Investigate the performance of a Deep Learning (DL)-based brain segmentation algorithm for 7T MR Images. Approach: We trained a DL model for volume-based morphometry using T1-weighted brain images acquired at 7T. We then evaluated model performance on 7T scans for 80 epilepsy patients scanned at both 7T and 3T. Segmentations and volumetric estimates obtained from the patients' scans at both field strengths were compared qualitatively and quantitatively. Results: We observed consistent aging trends, minimal volumetric discrepancies, and comparable atrophy patterns across field strengths. Impact: This work introduces a novel and reliable brain morphometry algorithm that provides detailed structural insight for enhanced clinical decision support in epilepsy care.

Official source

https://infoscience.epfl.ch/entities/publication/b7016283-d7f5-4960-97c5-2220edc3a8ea

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Jean-Philippe Thiran
2025

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/b7016283-d7f5-4960-97c5-2220edc3a8ea

About this result

Related concepts (32)

Magnetic resonance imaging

Magnetic resonance imaging (MRI) is a medical imaging technique used in radiology to form pictures of the anatomy and the physiological processes of the body. MRI scanners use strong magnetic fields, magnetic field gradients, and radio waves to generate images of the organs in the body. MRI does not involve X-rays or the use of ionizing radiation, which distinguishes it from computed tomography (CT) and positron emission tomography (PET) scans.

Epilepsy

Epilepsy is a group of non-communicable neurological disorders characterized by recurrent epileptic seizures. An epileptic seizure is the clinical manifestation of an abnormal, excessive, purposeless and synchronized electrical discharge in the brain cells called neurons. The occurrence of two or more unprovoked seizures defines epilepsy. The occurrence of just one seizure may warrant the definition (set out by the International League Against Epilepsy) in a more clinical usage where recurrence may be able to be prejudged.

Post-traumatic epilepsy

Post-traumatic epilepsy (PTE) is a form of acquired epilepsy that results from brain damage caused by physical trauma to the brain (traumatic brain injury, abbreviated TBI). A person with PTE experiences repeated post-traumatic seizures (PTS, seizures that result from TBI) more than a week after the initial injury. PTE is estimated to constitute 5% of all cases of epilepsy and over 20% of cases of acquired epilepsy (in which seizures are caused by an identifiable organic brain condition).

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Advancing Brain Morphometry at 7T: A Pilot Study on Epilepsy Patients

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