Publication

Enantioselective C-H Functionalization-Addition Sequence Delivers Densely Substituted 3-Azabicyclo[3.1.0]hexanes

Nicolai Cramer, Julia Pedroni
2017
Journal Articles

Abstract

An enantioselective C-H functioffalization route to perfluoroalkyl-containing 3-azabicyclo[3.1.0]-hexanes is disclosed. A modular and bench-stable diazaphospholane ligand enables highly enantioselective Pd(0)-catalyzed cyclopropane C-H functionalization using trifluoroacetimidoyl chlorides as electrophilic partners. In turn, the resulting cyclic ketimine products react smoothly with a broad variety of nudeophiles in one-pot processes enabling the rapid and modular construction of heavily substituted pyrrolidines.

Official source

https://infoscience.epfl.ch/entities/publication/b466bbc0-4279-4bf1-af10-c702193fc3b6

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