Publication

Study of interleukin absorption in a blood filtration element for plasma separation

Nico de Rooij, Alexandra Anne Labiba Kämpfer-Homsy
2011
Posters

Abstract

In clinical diagnostics, the fluidic part for sample-preparation should not absorb any of the substances of interest. In this study, the absorption of 4 different interleukins was investigated in a newly developed microfluidic blood filtration element (BFE). The BFE is capable of extracting 8-15 μL volume of plasma from 100 μL of whole blood in 7 minutes. Whole blood from 4 separate human subjects was tested. The recovery from our BFE was lower than 100%, but, as it was reproducible (except for TNF-α), enables use of the device in clinical trials with prior calibration.

Official source

https://infoscience.epfl.ch/entities/publication/b2a725d3-3ea4-426f-8528-45b0ecd2bf78

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Nico de Rooij, Alexandra Anne Labiba Kämpfer-Homsy
2011
Posters

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/b2a725d3-3ea4-426f-8528-45b0ecd2bf78

About this result

Related concepts (32)

Blood plasma

Blood plasma is a light amber-colored liquid component of blood in which blood cells are absent, but which contains proteins and other constituents of whole blood in suspension. It makes up about 55% of the body's total blood volume. It is the intravascular part of extracellular fluid (all body fluid outside cells). It is mostly water (up to 95% by volume), and contains important dissolved proteins (6–8%; e.g., serum albumins, globulins, and fibrinogen), glucose, clotting factors, electrolytes (Na+, Ca2+, Mg2+, , Cl−, etc.

Blood

Blood is a body fluid in the circulatory system of humans and other vertebrates that delivers necessary substances such as nutrients and oxygen to the cells, and transports metabolic waste products away from those same cells. Blood in the circulatory system is also known as peripheral blood, and the blood cells it carries, peripheral blood cells. Blood is composed of blood cells suspended in blood plasma.

Blood type

A blood type (also known as a blood group) is a classification of blood, based on the presence and absence of antibodies and inherited antigenic substances on the surface of red blood cells (RBCs). These antigens may be proteins, carbohydrates, glycoproteins, or glycolipids, depending on the blood group system. Some of these antigens are also present on the surface of other types of cells of various tissues. Several of these red blood cell surface antigens can stem from one allele (or an alternative version of a gene) and collectively form a blood group system.

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Study of interleukin absorption in a blood filtration element for plasma separation

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