Roles of Epigenetic Dysregulation in Cancer Progression and Metastasis

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Lung cancer is the leading cause of cancer-related deaths worldwide and the most common lung cancer subtype is lung adenocarcinoma (LUAD). Frequently mutated genes involve activating mutations in KRAS and loss of function mutations in TP53. LUADs primarily ...

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The present invention relates to 6-diazo-5-oxo-L-norleucine prodrugs having reduced toxicity and increased tumor specificity and to their therapeutic use for treating cancer. ...

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Cancer cell plasticity contributes to therapy resistance and metastasis, which represent the main causes of cancer-related death, including in breast cancer. The tumor microenvironment drives cancer cell plasticity and metastasis, and unraveling the underl ...

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Growing evidence indicates that transposable elements (TEs) play important roles in evolution by providing genomes with coding and non-coding sequences. Identification of TE-derived functional elements, however, has relied on TE annotations in individual s ...

Roles of Epigenetic Dysregulation in Cancer Progression and Metastasis

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The role of LRRK2 in lung adenocarcinoma

Cytokine-armed dendritic cell progenitors for antigen-agnostic cancer immunotherapy

A Cluster of Evolutionarily Recent KRAB Zinc Finger Proteins Protects Cancer Cells from Replicative Stress–Induced Inflammation

6-diazo-5-oxo-l-norleucine prodrugs

Next-Generation Modeling of Cancer Using Organoids

Development of cysteine cathepsin inhibitors combined with cell type-specific delivery for the treatment of B-cell lymphoma and solid tumors

Androgen Receptor Signaling in in vivo models of Estrogen Receptor-positive Breast Cancer and Normal Breast Epithelium

Ru(II)-Arene Complexes of Curcumin and Bisdesmethoxycurcumin Metabolites

Bioengineering functional organoid models across scales

The dynamic genetic determinants of increased transcriptional divergence in spermatids

Deciphering the nature of cell state transitions in single cells using quantitative modeling of temporal dynamics

Decoding Chromatin Ubiquitylation: A Chemical Biology Perspective

NMR and MS reveal characteristic metabolome atlas and optimize esophageal squamous cell carcinoma early detection

Bcl-xL targeting eliminates ageing tumor-promoting neutrophils and inhibits lung tumor growth

Exploration and modulation of mechanical cues for enhanced cancer immunotherapy

Tumor-educated Gr1+CD11b+cells drive breast cancer metastasis via OSM/IL-6/JAK-induced cancer cell plasticity

Inheritance of H3K9 methylation regulates genome architecture in Drosophila early embryos

Accessible and highly observable gastrointestinal organoid model systems for studying host-pathogen interactions

Single-cell epigenomic reconstruction of developmental trajectories from pluripotency in human neural organoid systems

Ancestral genome reconstruction enhances transposable element annotation by identifying degenerate integrants