Are monocytes a preferable option to develop myeloid cell-based therapies for solid tumors?

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The emergence of immunotherapy, including immune checkpoint blockade (ICB) and the adoptive transfer of cytotoxic lymphocytes, such as CAR-T cell therapy, has revolutionized cancer treatment. However, these therapies still face significant challenges in t ...

Modulating the metabolism of cancer cells, immune cells, or both is a promising strategy to potentiate cancer immunotherapy in the nutrient-competitive tumor microenvironment. Glutamine has emerged as an ideal target as cancer cells highly rely on glutamin ...

An efficient immune system must provide protection against a broad range of pathogens without causing excessive collateral tissue damage. While immune effectors have been well characterized, we know less about the resilience mechanisms protecting the host ...

Jamming of cell collectives and associated rigidity transitions have been shown to play a key role in tissue dynamics, structure and morphogenesis. Cellular jamming is controlled by cellular density and the mechanics of cell-cell contacts. However, the con ...

T cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy caused by acquisition of genetic alterations during T-cell development. The 5-year overall survival of pediatric T-ALL patients has improved considerably over the past 30 ...

Background and Objectives: Optimization of chemotherapy is crucial for cancer patients. Timely and costly efficient treatments are emerging due to the increasing incidence of cancer worldwide. Here, we present a methodology of nano-motion analysis that cou ...

Background Herbal medicines have been a major target for numerous studies through the past years as an alternative treatment for cancer, mainly due to their minimal effects on normal healthy cells. Annona cherimola, popularly known as Cherimoya, is an edib ...

Pathogen-derived nucleic acids are crucial signals for innate immunity. Despite the structural similarity between those and host nucleic acids, mammalian cells have been able to evolve powerful innate immune signaling pathways that originate from the detec ...

Hematopoietic stem cells (HSCs) are responsible for the continuous production of all blood cells. This unique ability has made it possible to successfully use HSCs in the clinical setting to remedy various blood disorders. However, despite six decades of r ...

Are monocytes a preferable option to develop myeloid cell-based therapies for solid tumors?

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Rational cytokine and receptor engineering for enhanced safety and efficacy of cancer immunotherapy

A redox-responsive prodrug for tumor-targeted glutamine restriction

A humoral stress response protects Drosophila tissues from antimicrobial peptides

A nuclear jamming transition in vertebrate organogenesis

Resistance mechanism to Notch inhibition and combination therapy in human T cell acute lymphoblastic leukemia

Nano-Motion Analysis for Rapid and Label Free Assessing of Cancer Cell Sensitivity to Chemotherapeutics

The selective anti-proliferative and pro-apoptotic effect of A. cherimola on MDA-MB-231 breast cancer cell line

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In vitro fate mapping of stem cell development at the single cell level

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Treatment of Parkinson's disease. Symptomatic cell therapies: cells as biological minipumps