Publication

Ascending Aortic Aneurysm in Angiotensin II–Infused Mice: Formation, Progression, and the Role of Focal Dissections

Related publications (30)

Ultrasound Imaging: From Physical Modeling to Deep Learning

Among the medical imaging modalities, ultrasound (US) imaging is one of the safest, most widespread, and least expensive method used in medical diagnosis. In the past decades, several technological advances enabled the advent of ultrafast US imaging, an ac ...

EPFL2021

Distinct types of plexiform lesions identified by synchrotron-based phase-contrast micro-CT

Goran Lovric

In pulmonary arterial hypertension, plexiform lesions are associated with severe arterial obstruction and right ventricular failure. Exploring their structure and position is crucial for understanding the interplay between hemodynamics and vascular remodel ...

AMER PHYSIOLOGICAL SOC2021

Vascular-targeted micelles as a specific MRI contrast agent for molecular imaging of fibrin clots and cancer cells

Anne-Sophie Chauvin, Vassily Vorobiev, Aurélien Thomas

Molecular medical imaging is intended to increase the accuracy of diagnosis, particularly in cardiovascular and cancer-related diseases, where early detection could significantly increase the treatment success rate. In this study, we present mixed micelles ...

ELSEVIER2021

Deep Learning Building on Prior Ischemic Core Segmentation Improves Prediction of Infarction After Stroke

Dimitri Nestor Alice Van De Ville, Elisabeth Anne Dirren, Guillaume Paul Olivier Leclerc, Maria Giulia Preti

Introduction: Imaging studies are used to guide patient selection for acute stroke treatment. Perfusion CT (pCT) is widely used to identify the acute ischemic core and penumbra, but the prediction of the final infarct remains challenging. With the advent o ...

LIPPINCOTT WILLIAMS & WILKINS2021

Early Morphofunctional Changes in AngII-Infused Mice Contribute to Regional Onset of Aortic Aneurysm and Dissection

Nikolaos Stergiopoulos, Bram Trachet, Lydia Aslanidou, Goran Lovric

Aortic aneurysms and dissections are silent and lethal conditions, whose pathogenesis remains incompletely understood. Although angiotensin II (AngII)-infused ApoE-/- mice have been widely used to study aortic aneurysm and dissection, early morphofunctiona ...

KARGER2020

Acute effects of transcatheter aortic valve replacement on the ventricular-aortic interaction

Nikolaos Stergiopoulos, Stamatia Zoi Pagoulatou, Vasiliki Bikia, Georgios Rovas

Transcatheter aortic valve replacement (TAVR) is increasingly used to treat severe aortic stenosis (AS) patients. However, little is known regarding the direct effect of TAVR on the ventricular-aortic interaction. In the present study, we aimed to investig ...

AMER PHYSIOLOGICAL SOC2020

The effect of the elongation of the proximal aorta on the estimation of the aortic wall distensibility

Nikolaos Stergiopoulos, Bram Trachet, Stamatia Zoi Pagoulatou, Mauro Ferraro, Vasiliki Bikia, Georgios Rovas

The compliance of the proximal aortic wall is a major determinant of cardiac afterload. Aortic compliance is often estimated based on cross-sectional area changes over the pulse pressure, under the assumption of a negligible longitudinal stretch during the ...

2021

Cardiotrophin-1 Deficiency Abrogates Atherosclerosis Progression

Nikolaos Stergiopoulos, Rodrigo Araujo Fraga Da Silva

Cardiotrophin-1 (CT-1) is associated with cardiovascular (CV) diseases. We investigated the effect of CT-1 deficiency in the development and progression of atherosclerosis in double knockout Apoe(-/-)ct-1(-/-) mice. Apoe(-/-) C57Bl/6 or Apoe(-/-)ct-1(-/-) ...

Nature Research2020

Noninvasive estimation of aortic hemodynamics and cardiac contractility using machine learning

Nikolaos Stergiopoulos, Stamatia Zoi Pagoulatou, Vasiliki Bikia, Georgios Rovas

Cardiac and aortic characteristics are crucial for cardiovascular disease detection. However, noninvasive estimation of aortic hemodynamics and cardiac contractility is still challenging. This paper investigated the potential of estimating aortic systolic ...

Nature Research2020

In vitro Implementation of Photopolymerizable Hydrogels as a Potential Treatment of Intracranial Aneurysms

Dominique Pioletti, Andreas Schmocker, Christophe Moser, Oriane Poupart

Intracranial aneurysms are increasingly being treated with endovascular therapy, namely coil embolization. Despite being minimally invasive, partial occlusion and recurrence are more frequent compared to open surgical clipping. Therefore, an alternative tr ...

2020