Publications related to Partial-volume modeling reveals reduced gray matter in specific thalamic nuclei early in the time course of psychosis and chronic schizophrenia

Related publications (34)

Neuroimaging to Guide the Delivery of Implantable Neuroprosthetics Restoring Neurological Functions

Spinal cord injury (SCI) and Parkinson's disease (PD) are debilitating conditions that severely disrupt motor and autonomic functions, profoundly affecting the quality of life for millions worldwide. Over the past few decades, epidural electrical stimulati ...

EPFL2025

synMARSS—An End-To-End Platform for the Parametric Generation of Synthetic In Vivo Magnetic Resonance Spectra

André Döring

Synthetic magnetic resonance spectra (MRS) are mathematically generated spectra which can be used to investigate the assumptions of data analysis strategies, optimize experimental design, and as training data for the development and validation of machine l ...

2025

Thalamic contributions to psychosis susceptibility: Evidence from co-activation patterns accounting for intra-seed spatial variability (μCAPs)

Dimitri Nestor Alice Van De Ville, Thomas William Arthur Bolton, Farnaz Delavari

The temporal variability of the thalamus in functional networks may provide valuable insights into the pathophysiology of schizophrenia. To address the complexity of the role of the thalamic nuclei in psychosis, we introduced micro-co-activation patterns ( ...

Wiley2024

White adipose tissue distribution and amount are associated with increased white matter connectivity

Jean-Philippe Thiran, Gabriel Girard, Elda Fischi Gomez, Philipp Johannes Koch

Obesity represents a significant public health concern and is linked to various comorbidities and cognitive impairments. Previous research indicates that elevated body mass index (BMI) is associated with structural changes in white matter (WM). However, a ...

Wiley2024

Neurocognition and NMDAR co-agonists pathways in individuals with treatment resistant first-episode psychosis: a 3-year follow-up longitudinal study

Lijing Xin

This study aims to determine whether 1) individuals with treatment-resistant schizophrenia display early cognitive impairment compared to treatment-responders and healthy controls and 2) N-methyl-D-aspartate-receptor hypofunction is an underlying mechanism ...

Springernature2024

Transdiagnostic markers across the psychosis continuum: a systematic review and meta-analysis of resting state fMRI studies

Dimitri Nestor Alice Van De Ville, Farnaz Delavari

Psychotic symptoms are among the most debilitating and challenging presentations of severe psychiatric diseases, such as schizophrenia, schizoaffective, and bipolar disorder. A pathophysiological understanding of intrinsic brain activity underlying psychos ...

Frontiers Media Sa2024

Genome-wide analysis of the biophysical properties of chromatin and nuclear proteins in living cells with Hi-D

Marwan Muhammad Ahmed Abdellah

To understand the dynamic nature of the genome, the localization and rearrangement of DNA and DNA-binding proteins must be analyzed across the entire nucleus of single living cells. Recently, we developed a computational light microscopy technique, called ...

Nature Publishing Group2024

Non-invasive deep brain stimulation: interventional targeting of deep brain areas in neurological disorders

Friedhelm Christoph Hummel

Recently developed non-invasive deep brain stimulation methods have sufficient focal specificity to target deep brain structures. These techniques show particular promise as treatment strategies for neuropsychiatric disorders in which deep brain structures ...

NATURE PORTFOLIO2024

Transportation-based functional ANOVA and PCA for covariance operators

Victor Panaretos, Yoav Zemel, Valentina Masarotto

We consider the problem of comparing several samples of stochastic processes with respect to their second-order structure, and describing the main modes of variation in this second order structure, if present. These tasks can be seen as an Analysis of Vari ...

Inst Mathematical Statistics-Ims2024

Subcortical correlates of consciousness with human single neuron recordings

Olaf Blanke, Fosco Bernasconi, Nathan Quentin Faivre, Michael Eric Anthony Pereira

Subcortical brain structures such as the basal ganglia or the thalamus are involved in regulating motor and cognitive behavior. However, their contribution to perceptual consciousness is still unclear, due to the inherent difficulties of recording subcorti ...

2024

Reliable data-driven decision-making through optimal transport

Bahar Taskesen

Decision-making permeates every aspect of human and societal development, from individuals' daily choices to the complex decisions made by communities and institutions. Central to effective decision-making is the discipline of optimization, which seeks th ...

EPFL2024

The hindbrain and cortico-reticular pathway in adolescent idiopathic scoliosis

Bénédicte Marie Maréchal

AIM: To characterise the corticoreticular pathway (CRP) in a case -control cohort of adolescent idiopathic scoliosis (AIS) patients using high -resolution slice -accelerated readoutsegmented echo -planar diffusion tensor imaging (DTI) to enhance the discri ...

W B Saunders Co Ltd2024

Interrelation between cardiac and brain small-vessel disease: a pilot quantitative PET and MRI study

Bénédicte Marie Maréchal, Ricardo Alberto Corredor Jerez

Background: Small-vessel disease (SVD) plays a crucial role in cardiac and brain ischemia, but little is known about potential interrelation between both. We retrospectively evaluated 370 patients, aiming at assessing the interrelation between cardiac and ...

Springernature2023

Non-invasive stimulation of the human striatum disrupts reinforcement learning of motor skills

Friedhelm Christoph Hummel, Takuya Morishita, Maximilian Jonas Wessel, Elena Beanato, Traian Popa, Pierre Theopistos Vassiliadis, Fabienne Windel, Esra Neufeld

Reinforcement feedback can improve motor learning, but the underlying brain mechanisms remain underexplored. In particular, the causal contribution of specific patterns of oscillatory activity within the human striatum is unknown. To address this question, ...

Nature Portfolio2024

New insights into rodent brain microstructure and metabolism in hepatic encephalopathy

Jessie Julie Mosso

Type C hepatic encephalopathy (HE) is a severe neuropsychiatric complication of chronic liver disease, for which the prognosis is poor in the absence of liver transplantation. Cirrhosis in type C HE leads to a toxic accumulation of ammonia in the blood, wh ...

EPFL2023

Stroke Recovery–Related Changes in Cortical Reactivity Based on Modulation of Intracortical Inhibition

Dimitri Nestor Alice Van De Ville, Olaf Blanke, Silvestro Micera, Takuya Morishita, Elena Beanato, Sylvain Jean-François Harquel, Philip Egger, Lisa Aïcha Mireille Julie Fleury, Giorgia Giulia Evangelista, Pauline Menoud, Martino Bruno Armando Ceroni, Adrien Jean-Baptiste Witon

BACKGROUND: Cortical excitation/inhibition dynamics have been suggested as a key mechanism occurring after stroke. Their supportive or maladaptive role in the course of recovery is still not completely understood. Here, we used transcranial m ...

Ovid Technologies (Wolters Kluwer Health)2024

Robust Estimation of the Microstructure of the Early Developing Brain Using Deep Learning

Meritxell Bach Cuadra, Rizhong Lin

Diffusion Magnetic Resonance Imaging (dMRI) is a powerful non-invasive method for studying white matter tracts of the brain. However, accurate microstructure estimation with fiber orientation distribution (FOD) using existing computational methods requires ...

Springer2023

Behavioral outcome of very preterm children at 5 years of age: Prognostic utility of brain tissue volumes at term-equivalent-age, perinatal, and environmental factors

Djalel Eddine Meskaldji, Serafeim Loukas

ObjectivePrematurity is associated with a high risk of long-term behavioral problems. This study aimed to assess the prognostic utility of volumetric brain data at term-equivalent-age (TEA), clinical perinatal factors, and parental social economic risk in ...

WILEY2023

Longitudinal evaluation of the mechanisms supporting post-stroke motor recovery using TMS-EEG coupling

Andéol Geoffroy Cadic-Melchior

Stroke is the main source of long-lasting disability, affecting dominantly motor functions. The extent and course of recovery are highly heterogeneous between patients, with a minority of patients fully recovering from their initial impairments, leaving 85 ...

EPFL2023

A striatal circuit balances learned fear in the presence and absence of sensory cues

Ralf Schneggenburger, Olexiy Kochubey, Michael Kintscher

During fear learning, defensive behaviors like freezing need to be finely balanced in the presence or absence of threat-predicting cues (conditioned stimulus, CS). Nevertheless, the circuits underlying such balancing are largely unknown. Here, we investiga ...

eLIFE SCIENCES PUBL LTD2023