Publication

New Synthetic Methodologies for Amphiphilic Multiblock Copolymers of Ethylene Glycol and Propylene Sulfide

2001
Journal Articles

Abstract

A one pot synthetic method was developed for prepn. of amphiphilic block copolymers using episulfide anionic polymn. for generating sym. or asym. tri- or multi-block copolymers via living mechanism. The method is based on in situ generated thiolates, which ensures reproducibility of initiator concn. The mild character of the reactive species allows for incorporation of sensitive bioactive groups into the polymer structure. The polymers obtained are poly(ethylene glycol-propylene sulfide) diblocks (PEG-b-PPS) and sym. PEG-b-PPS-b-PEG triblocks. The method shows tolerance for impurities in reagents and in the one pot environment, which allows its use by operators with limited skills in org. synthesis. The PEG-b-PPS-b-PEG copolymers show lyotropic properties. [on SciFinder (R)]

Official source

https://infoscience.epfl.ch/entities/publication/af2f7032-e29a-4967-8e5f-be1b6790aa4c

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2001
Journal Articles

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/af2f7032-e29a-4967-8e5f-be1b6790aa4c

About this result

Related concepts (10)

Copolymer

In polymer chemistry, a copolymer is a polymer derived from more than one species of monomer. The polymerization of monomers into copolymers is called copolymerization. Copolymers obtained from the copolymerization of two monomer species are sometimes called bipolymers. Those obtained from three and four monomers are called terpolymers and quaterpolymers, respectively. Copolymers can be characterized by a variety of techniques such as NMR spectroscopy and size-exclusion chromatography to determine the molecular size, weight, properties, and composition of the material.

Micelle

A micelle (maɪˈsɛl) or micella (maɪˈsɛlə) (plural micelles or micellae, respectively) is an aggregate (or supramolecular assembly) of surfactant amphipathic lipid molecules dispersed in a liquid, forming a colloidal suspension (also known as associated colloidal system). A typical micelle in water forms an aggregate with the hydrophilic "head" regions in contact with surrounding solvent, sequestering the hydrophobic single-tail regions in the micelle centre. This phase is caused by the packing behavior of single-tail lipids in a bilayer.

Amphiphile

An amphiphile (from the Greek αμφις amphis, both, and φιλíα philia, love, friendship), or amphipath, is a chemical compound possessing both hydrophilic (water-loving, polar) and lipophilic (fat-loving) properties. Such a compound is called amphiphilic or amphipathic. Amphiphilic compounds include surfactants (these detergents are commonly called "soap" but are different from traditional soap in both composition and method of action for cleaning). The phospholipid amphiphiles are the major structural component of cell membranes.