Publication

Megapixel time-gated SPAD image sensor for scientific imaging applications

Claudio Bruschini
2021
Talks

Abstract

We present a 1 megapixel single-photon avalanche diode (SPAD) camera featuring 3.8 ns time gating and 24 kfps frame rate for 1-bit images, fabricated in 180 nm CMOS image sensor technology. The SPAD sensor was used to capture 2D and 3D scenes over 2 m with depth resolution of 5.4 mm and precision better than 7.8 mm (rms). We demonstrate extended dynamic range in dual exposure operation mode and show spatially overlapped multi-object detection in single-photon time-gated time-of-flight experiments. We further demonstrate applications of the megapixel SPAD camera for fluorescence lifetime imaging microscopy (FLIM) and light-in-flight imaging.

Official source

https://infoscience.epfl.ch/entities/publication/aebb410b-0d95-42d0-bea7-b8fe0bf8bdf5

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Claudio Bruschini
2021
Talks

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/aebb410b-0d95-42d0-bea7-b8fe0bf8bdf5

About this result

Related concepts (13)

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Fluorescence is used in the life sciences generally as a non-destructive way of tracking or analysing biological molecules. Some proteins or small molecules in cells are naturally fluorescent, which is called intrinsic fluorescence or autofluorescence (such as NADH, tryptophan or endogenous chlorophyll, phycoerythrin or green fluorescent protein). Alternatively, specific or general proteins, nucleic acids, lipids or small molecules can be "labelled" with an extrinsic fluorophore, a fluorescent dye which can be a small molecule, protein or quantum dot.

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Megapixel time-gated SPAD image sensor for scientific imaging applications

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