Simulation and Theory of Antibody Binding to Crowded Antigen-Covered Surfaces

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Proteins, the central building blocks of life, play pivotal roles in nearly every biological function. To do so, these macromolecular structures interact with their surrounding environment in complex ways, leading to diverse functional behaviors. The predi ...

Protein-based therapeutics, such as monoclonal antibodies and cytokines, are important therapies for various pathophysiological conditions such as oncology, autoimmune disorders, and viral infections. However, the wide application of such protein therapeut ...

A peptide was developed that binds to calprotectin, a marker of major inflammatory disorders, and found to be suited for diagnostic tests. The use of synthetic peptides in assays is of great interest due to their high precision, robustness and low price. ...

Template-directed methods are emerging as some of the most effective means to conjugate payloads at selective sites of monoclonal antibodies (mAbs). We have previously reported a method based on an engineered Fc-III reactive peptide to conjugate a radionuc ...

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Simulation and Theory of Antibody Binding to Crowded Antigen-Covered Surfaces

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A Geometric Transformer for Structural Biology: Development and Applications of the Protein Structure Transformer

Rational Design of Chemically Controlled Antibodies and Protein Therapeutics

High-affinity peptides developed against calprotectin and their application as synthetic ligands in diagnostic assays

Site-selective template-directed synthesis of antibody Fc conjugates with concomitant ligand release

De novo designed proteins: a study in engineering novel folds and functions

Monitoring of Protein and pH Levels in Human Biofluids using FD-SOI Silicon Nanowire Arrays

Development of a novel Chimeric Antigen Receptor (CAR) for its use in Natural Killer (NK) cells for cancer treatment and beyond

Computational design of dynamic receptor—peptide signaling complexes applied to chemotaxis

Computational Studies for the Design of Metalloenzyme Mimics

Nanomole-scale photochemical thiol-ene chemistry for high-throughput late-stage diversification of peptide macrocycles