Publication

Dynamics of lactate concentration and blood oxygen level-dependent effect in the human visual cortex during repeated identical stimuli

Rolf Gruetter
2007
Journal Articles

Abstract

In vivo 1H NMR spectroscopy at 7 T was utilized to measure the changes in lactate concentration upon repeated identical visual stimuli, each lasting for 2 min. The average amplitude of these increases was found to be reduced over time (P < 0.01), from 0.13 ± 0.02 μmol/g during the first half of the stimulation paradigm, to 0.06 ± 0.02 μmol/g during the second half of the stimulation paradigm. In contrast, the blood oxygen level-dependent (BOLD) effect on the fMRI water signal and on the height of the total creatine signal at 3.03 ppm was persistent during the whole observation period. This finding may suggest a differential adaptation of cortical output that is not reflected at the level of the global excitation-inhibition activity of the cortical canonical circuits. Alternative possibilities that could account for an adaptation of [Lac] changes are also discussed. © 2007 Wiley-Liss, Inc.

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https://infoscience.epfl.ch/entities/publication/adf91d34-eeb5-4d13-9b9f-a84e899412cc

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Rolf Gruetter
2007
Journal Articles

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/adf91d34-eeb5-4d13-9b9f-a84e899412cc

About this result

Related concepts (27)

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The cerebral cortex, also known as the cerebral mantle, is the outer layer of neural tissue of the cerebrum of the brain in humans and other mammals. The cerebral cortex mostly consists of the six-layered neocortex, with just 10% consisting of allocortex. It is separated into two cortices, by the longitudinal fissure that divides the cerebrum into the left and right cerebral hemispheres. The two hemispheres are joined beneath the cortex by the corpus callosum. The cerebral cortex is the largest site of neural integration in the central nervous system.

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In neuroscience, the visual P200 or P2 is a waveform component or feature of the event-related potential (ERP) measured at the human scalp. Like other potential changes measurable from the scalp, this effect is believed to reflect the post-synaptic activity of a specific neural process. The P2 component, also known as the P200, is so named because it is a positive going electrical potential that peaks at about 200 milliseconds (varying between about 150 and 275 ms) after the onset of some external stimulus.

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