Publication

Selective Functionalization of 2-Fluoropyridine, 2,3-Difluoropyridine, and 2,5-Difluoropyridine at Each Vacant Position

Manfred Schlosser
2005
Journal Articles

Abstract

The concept of "regioexhaustive substitution" has been successfully applied to 2-fluoro-, 2,3-difluoro-, and 2,5-difluoropyridine. All vacant positions were amenable to regioselective metalation and subsequent carboxylation by employing either chlorine as a neighboring site activating protective group or trimethylsilyl as a neighboring site screening protective group. In this way, approx. half a dozen fluorinated pyridinecarboxylic acids were derived from each starting material. [on SciFinder (R)]

Official source

https://infoscience.epfl.ch/entities/publication/ad8c23df-8350-4aa6-bb22-f712eac59b38

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Selective Functionalization of 2-Fluoropyridine, 2,3-Difluoropyridine, and 2,5-Difluoropyridine at Each Vacant Position

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