Publication

Functional Models of the Nickel Pincer Nucleotide Cofactor of Lactate Racemase

Xile Hu, Farzaneh Fadaei Tirani, Matthew Wodrich, Renyi Shi
2019
Journal Articles

Abstract

A novel nickel pincer cofactor was recently discovered in lactate racemase. Reported here are three synthetic nickel pincer complexes that are both structural and functional models of the pincer cofactor in lactate racemase. DFT computations suggest the ipso-carbon atom of the pyridinium pincer ligands act as a hydride acceptor for lactate isomerization, whereas an organometallic pathway involving nickel-mediated beta-hydride elimination is less favored.

Official source

https://infoscience.epfl.ch/entities/publication/aceb7333-8e33-42aa-aa59-026936d7a731

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Functional Models of the Nickel Pincer Nucleotide Cofactor of Lactate Racemase

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