Publications related to Point-of-care ultrasound for tuberculosis management in Sub-Saharan Africa-a balanced SWOT analysis

Laser-based ultrasound inspection system

Romain Christophe Rémy Fleury, Janez Rus

A laser-based ultrasound inspection system comprising an object for inspection (1), a laser device for ultrasound generation (3a), a laser device for ultrasound detection (3b), and a coating arrangement (4) including a laser absorbing layer (4a) disposed o ...

2024

Inverse Problems in Pulse-Echo Ultrasound: Exploiting Coherence for Image Enhancement and Quantitative Imaging

Samuel Denys Beuret

Whereas pulse-echo ultrasound imaging relied on focused acoustic waves since its inception, the last two decades have seen the development of techniques based on unfocused waves, including ultrafast ultrasound imaging. In large part due to the emergence of ...

EPFL2024

Reduced Training Data for Laser Ultrasound Signal Interpretation by Neural Networks

Romain Christophe Rémy Fleury, Janez Rus

The performance of machine learning algorithms is conditioned by the availability of training datasets, which is especially true for the field of nondestructive evaluation. Here we propose one reconfigurable specimen instead of numerous reference specimens ...

2024

Single-cell analysis of the interactions between Mycobacterium tuberculosis and macrophages

Ophélie Rutschmann

Mycobacterium Tuberculosis is a highly effective pathogen infecting nearly a third of the world's population. An M. tuberculosis infection starts when droplets containing bacteria enter an individual's lungs. The first host cells to contact the bacteria ar ...

EPFL2024

Defining and targeting tumor-associated macrophages in malignant mesothelioma

Michele De Palma

Defining the ontogeny of tumor-associated macrophages (TAM) is important to develop therapeutic targets for mesothelioma. We identified two distinct macrophage populations in mouse peritoneal and pleural cavities, the monocyte-derived, small peritoneal/ple ...

National Academy of Sciences2023

Back-to-Africa introductions of Mycobacterium tuberculosis as the main cause of tuberculosis in Dar es Salaam, Tanzania

Jacques Fellay, Zhi Ming Xu

In settings with high tuberculosis (TB) endemicity, distinct genotypes of the Mycobacterium tuberculosis complex (MTBC) often differ in prevalence. However, the factors leading to these differences remain poorly understood. Here we studied the MTBC populat ...

PUBLIC LIBRARY SCIENCE2023

Perfluorocarbon emulsion enhances MR-ARFI displacement and temperature in vitro: Evaluating the response with MRI, NMR, and hydrophone

Mohamed Farhat, Ryan Holman, Davide Bernardo Preso

Sonosensitive perfluorocarbon F(8)TAC(18)-PFOB emulsion is under development to enhance heating, increase thermal contrast, and reduce treatment times during focused ultrasound tumor ablation of highly perfused tissue. The emulsion previously showed enhanc ...

FRONTIERS MEDIA SA2023

Host-Pathogen Interactions Through the Genomic Lens

Zhi Ming Xu

Hosts and pathogens are involved in a long-standing evolutionary arms race characterized by successive rounds of evolution. Specifically, while hosts evolve resistance against infections, pathogens adapt to re-establish virulence. Since the signatures of t ...

EPFL2023

Multi-site, Multi-domain Airway Tree Modeling

Boyu Zhang, Jiancheng Yang, Ying Zhu, Yi Wu

Open international challenges are becoming the de facto standard for assessing computer vision and image analysis algorithms. In recent years, new methods have extended the reach of pulmonary airway segmentation that is closer to the limit of image resolut ...

Elsevier2023

A Wearable Ultrasound Interface for Prosthetic Hand Control

Xingchen Yang

Ultrasound can non-invasively detect muscle deformations and has great potential applications in prosthetic hand control. Traditional ultrasound equipment was usually too bulky to be applied in wearable scenarios. This research presented a compact ultrasou ...

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC2022

Wearable Ultrasound Interface for Prosthetic Hand Manipulation

Xingchen Yang

Ultrasound can non-invasively detect muscle deformations, which has great potential applications in prosthetic hand control. This research developed a miniaturized ultrasound device that could be integrated into a prosthetic hand socket. This compact syste ...

SPRINGER INTERNATIONAL PUBLISHING AG2022

Sonomyographic Prosthetic Interacion: Online Simultaneous and Proportional Control of Wrist and Hand Motions Using Semisupervised Learning

Xingchen Yang

Human hands play a very important role in daily object manipulation. Current prosthetic hands are capable of mimicking most functions of the human hand, but how to interact with prosthetic hands based on human intentions remains an open problem. In this ar ...

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC2022

Preexisting Heterogeneity of Inducible Nitric Oxide Synthase Expression Drives Differential Growth of Mycobacterium tuberculosis in Macrophages

John McKinney, Ophélie Rutschmann, Chiara Toniolo

Mycobacterium tuberculosis infection is initiated by the inhalation and implantation of bacteria in the lung alveoli, where they are phagocytosed by macrophages. Even a single bacterium may be sufficient to initiate infection. Thereafter, the clinical outc ...

AMER SOC MICROBIOLOGY2022

Ultrasound Imaging: From Physical Modeling to Deep Learning

Dimitris Perdios

Among the medical imaging modalities, ultrasound (US) imaging is one of the safest, most widespread, and least expensive method used in medical diagnosis. In the past decades, several technological advances enabled the advent of ultrafast US imaging, an ac ...

EPFL2021

Imaging atelectrauma in Ventilator-Induced Lung Injury using 4D X-ray microscopy

Anders Larsson, Goran Lovric

Mechanical ventilation can damage the lungs, a condition called Ventilator-Induced Lung Injury (VILI). However, the mechanisms leading to VILI at the microscopic scale remain poorly understood. Here we investigated the within-tidal dynamics of cyclic recru ...

NATURE RESEARCH2021

Contrast-Enhanced Ultrasound Quantification: From Kinetic Modeling To Machine Learning

Marcel Arditi

Ultrasound contrast agents (UCAs) have opened up immense diagnostic possibilities by combined use of indicator dilution principles and dynamic contrast-enhanced ultrasound (DCE-US) imaging. UCAs are microbubbles encapsulated in a biocompatible shell. With ...

2020

Toward Robust Sensing for Autonomous Vehicles: An Adversarial Perspective

Pascal Frossard, Andrea Cavallaro, Apostolos Modas

Autonomous vehicles (AVs) rely on accurate and robust sensor observations for safety-critical decision making in a variety of conditions. The fundamental building blocks of such systems are sensors and classifiers that process ultrasound, radar, GPS, lidar ...

2020

FasR Regulates Fatty Acid Biosynthesis and Is Essential for Virulence of Mycobacterium tuberculosis

Stewart Cole, Claudia Sala

Mycobacterium tuberculosis, the etiologic agent of human tuberculosis, is the world's leading cause of death from an infectious disease. One of the main features of this pathogen is the complex and dynamic lipid composition of the cell envelope, which adap ...

Frontiers Media SA2020

Polarly Localized EccE(1) Is Required for ESX-1 Function and Stabilization of ESX-1 Membrane Proteins in Mycobacterium tuberculosis

Stewart Cole, Claudia Sala, Ming Zhang, Jérémie Piton, Paloma Julia Soler Arnedo

Mycobacterium tuberculosis is a slow-growing intracellular bacterium with the ability to induce host cell death and persist indefinitely in the human body. This pathogen uses the specialized ESX-1 secretion system to secrete virulence factors and potent im ...

American Society for Microbiology2020

Time-lapse high-resolution microscopy to study the morphogenesis of microorganisms

Mélanie Thérèse Marie Hannebelle

Mycobacterium tuberculosis, the etiological agent for the tuberculosis disease, is a bacterial pathogen thought to infect about a quarter of the global human population. It is the first cause of death among infectious diseases, and is most prevalent in low ...

EPFL2020