Building biosecurity for synthetic biology

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Native reactive electrophile species (RES) such as 4-hydroxynonenal (HNE) act as cellular signals through covalent modification of kinetically-privileged electrophile sensor proteins. Research efforts in the field focus mainly on identifying these sensor p ...

Recent studies suggested that long-lived photooxidants (LLPO), which are reactive intermediates formed during irradiation of dissolved organic matter (DOM), may consist of phenoxyl radicals derived from phenolic moieties of the DOM. Besides the well-studie ...

The magnetic propertiesof transition-metal ions aregenerallydescribed by the atomic spins of the ions and their exchange coupling.The orbital moment, usually largely quenched due the ligand field,is then seen as a perturbation. In such a scheme, S = 1/2 io ...

Cells of two molecular genetic types of breast cancer-hormone-dependent breast cancer (ZR-75 cell line) and triple-negative breast cancer (BT-20 cell line)-were studied using atomic force microscopy and an optical nanomotion detection method. Using the Pea ...

The presence of competing events, such as death, makes it challenging to define causal effects on recurrent outcomes. In this thesis, I formalize causal inference for recurrent events, with and without competing events. I define several causal estimands an ...

A data storage medium (2) comprising a stacked plurality of layers (9), each layer composed of a layer material selected from a group comprising at least two different dielectric materials, adjacent layers being formed of different materials, and at least ...

Near-surface wind is difficult to estimate using global numerical weather and climate models, because airflow is strongly modified by underlying topography, especially that of a country such as Switzerland. In this article, we use a statistical approach ba ...

Background: The development of therapeutics for Parkinson's disease (PD) requires the establishment of biomarker assays to enable stratifying patients, monitoring disease progression, and assessing target engagement. Attempts to develop diagnostic assays b ...

The beginning of the 21st century was marked by the advent of disruptive technologies, which ushered an era of groundbreaking advances in fundamental sciences, carried by the great pace at which computational capabilities spread and evolved. But the new ce ...

In competing event settings, a counterfactual contrast of cause-specific cumulative incidences quantifies the total causal effect of a treatment on the event of interest. However, effects of treatment on the competing event may indirectly contribute to thi ...

Modelling and analysis of biological systems is crucial in order to quantitatively explain and predict their behaviour. The importance of modelling in systems biology becomes even more evident when tackling complex, large systems. Approaches that rely on ...

We construct (modified) scattering operators for the Vlasov–Poisson system in three dimensions, mapping small asymptotic dynamics as t→−∞ to asymptotic dynamics as t→+∞. The main novelty is the construction of modified wave operators, but we also obtain a ...

In the Wendelstein 7-X (W7-X) stellarator, the vacuum rotational transform, ι, has a flat radial profile and does not cross any major rational resonance. Nevertheless, during plasma operation the ι‐profile can be strongly modified by electron cyclotron cur ...

Microbial consortia are a promising alternative to monocultures of genetically modified microorganisms for complex biotransformations. We developed a versatile consortium-based strategy for the direct conversion of lignocellulose to short-chain fatty acids ...

Background Alzheimer's disease (AD) is a complex disorder caused by a combination of genetic and non-genetic risk factors. In addition, an increasing evidence suggests that epigenetic mechanisms also accompany AD. Genetic and epigenetic factors are not ind ...

Here we report the design of a disposable single-drop voltammetric sensor for the quantitative determination of antipsy-chotic drug trifluoperazine (TFP). The sensor was build using inkjet-printed carbon nanotube (CNT) electrodes which were modified with d ...

Temperature is one of the most important range-limiting factors for many seaweeds. Driven by the recent climatic changes, rapid northward shifts of species' distribution ranges can potentially modify the phylogeographic signature of Last Glacial Maximum. W ...

Assays focusing on emerging biological phenomena in an animal's life can be performed during embryogenesis. While the embryo of Caenorhabditis elegans has been extensively studied, its biomechanical properties are largely unknown. Here, we demonstrate that ...

Cu-polyester (Cu-PES) was sputtered by high power impulse magnetron sputtering (HIPIMS) and by low energy direct current magnetron sputtering (DCMS). The total amount and distribution of the Ar+, Cu+ and Cu2+ ions were determined as well as the bacterial i ...

An electrochemical sensor is described for the determination of L-dopa (levodopa; 3,4-dihydroxyphenylalanine). An inkjet-printed carbon nanotube (IJPCNT) electrode was modified with manganese dioxide microspheres by drop-casting. They coating was character ...

Building biosecurity for synthetic biology

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Towards Uncovering the Mechanisms of Electrophile Sensing and Signaling

Impact of chlorination and ozonation of dissolved organic matter on its photo-induced production of long-lived photooxidants and excited triplet states

Large Orbital Moment of Two Coupled Spin-Half Co Ions in a Complex on Gold

Mechanical Properties and Nanomotion of BT-20 and ZR-75 Breast Cancer Cells Studied by Atomic Force Microscopy and Optical Nanomotion Detection Method

Interventionist estimands in event history analysis

Non-volatile data storage medium and system

Downscaling of Historical Wind Fields over Switzerland Using Generative Adversarial Networks

Comparative Analysis of Total Alpha-Synuclein (alpha SYN) Immunoassays Reveals That They Do Not Capture the Diversity of Modified alpha SYN Proteoforms

New and improved methods for integrated models of metabolism and gene expression

A generalized theory of separable effects in competing event settings

Modelling the Intracellular Environment under Uncertainty, from Post-translational Modification to Metabolic Networks

Scattering Map for the Vlasov–Poisson System

Model for current drive induced crash cycles in W7-X

A heterogeneous microbial consortium producing short-chain fatty acids from lignocellulose

Comprehensive analysis of PM20D1 QTL in Alzheimer's disease

Inkjet-Printed Carbon Nanotube Electrodes Modified with Dimer-captosuccinic Acid-Capped Fe3O4 Nanoparticles on Reduced Graphene Oxide Nanosheets for Single-Drop Determination of Trifluoperazine

Seascape Genomics of the Sugar Kelp Saccharina latissima along the North Eastern Atlantic Latitudinal Gradient

Force microscopy of the Caenorhabditis elegans embryonic eggshell

Monitoring the energy of the metal ion-content plasma-assisted deposition and its implication for bacterial inactivation

Point-of-care amperometric determination of L-dopa using an inkjet-printed carbon nanotube electrode modified with dandelion-like MnO2 microspheres