Publication

Evaluation of generative models for synthetic CT images using SINGHA, a new spectrally informed metric

Jean-Philippe Thiran
2024

Abstract

Motivation: Synthetic CT (sCT) based on MRI could improve the characterization of bone pathology by estimating bone mineral density and providing a high level of structural details. However, evaluating the performance of sCT is challenging in both respects. Goal(s): To propose an evaluation framework for sCT that quantifies accuracy both in terms of image intensity and depiction of structural details. Approach: We propose the new frequency-based metric SINGHA that captures the sharpness difference between images. Results: SINGHA was complementary to standard metrics and captured differences in high frequency content, thereby contributing to a more comprehensive evaluation of sCT images. Impact: Using the newly introduced Spectrally-INformed Grading of High-frequency Attributes (SINGHA) in conjunction with standard intensity-based metrics enables to simultaneously evaluate synthetic CT accuracy in terms of bone mineral density and sharpness.

Official source

https://infoscience.epfl.ch/entities/publication/abb0ba38-cbb7-4a8e-aa75-fd772ec55389

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Jean-Philippe Thiran
2024

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/abb0ba38-cbb7-4a8e-aa75-fd772ec55389

About this result

Related concepts (31)

Bone density

Bone density, or bone mineral density, is the amount of bone mineral in bone tissue. The concept is of mass of mineral per volume of bone (relating to density in the physics sense), although clinically it is measured by proxy according to optical density per square centimetre of bone surface upon imaging. Bone density measurement is used in clinical medicine as an indirect indicator of osteoporosis and fracture risk. It is measured by a procedure called densitometry, often performed in the radiology or nuclear medicine departments of hospitals or clinics.

Osteopenia

Osteopenia, known as "low bone mass" or "low bone density", is a condition in which bone mineral density is low. Because their bones are weaker, people with osteopenia may have a higher risk of fractures, and some people may go on to develop osteoporosis. In 2010, 43 million older adults in the US had osteopenia. Unlike osteoporosis, osteopenia does not usually cause symptoms, and losing bone density in itself does not cause pain.

Bone

A bone is a rigid organ that constitutes part of the skeleton in most vertebrate animals. Bones protect the various other organs of the body, produce red and white blood cells, store minerals, provide structure and support for the body, and enable mobility. Bones come in a variety of shapes and sizes and have complex internal and external structures. They are lightweight yet strong and hard and serve multiple functions. Bone tissue (osseous tissue), which is also called bone in the uncountable sense of that word, is hard tissue, a type of specialised connective tissue.

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Evaluation of generative models for synthetic CT images using SINGHA, a new spectrally informed metric

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