Publication

Multistage carcinogenesis and the fraction at risk

Stephan Morgenthaler
2004
Journal Articles

Abstract

Multistage carcinogenesis models describe the evolution of the cells in an individual's organ from a normal stage to a pre-neoplastic stage to a neoplastic stage. The triggers for the passage from one stage to the next one are presumed to be genetic alterations, which are not only governed by purely random events but also by individual environmental and genetic factors. We generalize existing models of carcinogenesis to populations composed of heterogeneous individuals, thus taking the environmental and genetic variability into account.

Official source

https://infoscience.epfl.ch/entities/publication/ab5134d1-ce0d-43ed-907f-c76a11855a55

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Stephan Morgenthaler
2004
Journal Articles

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/ab5134d1-ce0d-43ed-907f-c76a11855a55

About this result

Related concepts (32)

Carcinogenesis

Carcinogenesis, also called oncogenesis or tumorigenesis, is the formation of a cancer, whereby normal cells are transformed into cancer cells. The process is characterized by changes at the cellular, genetic, and epigenetic levels and abnormal cell division. Cell division is a physiological process that occurs in almost all tissues and under a variety of circumstances. Normally, the balance between proliferation and programmed cell death, in the form of apoptosis, is maintained to ensure the integrity of tissues and organs.

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The environmental movement (sometimes referred to as the ecology movement), is a social movement that aims to protect the natural world from harmful environmental practices in order to create sustainable living. Environmentalists advocate the just and sustainable management of resources and stewardship of the environment through changes in public policy and individual behavior. In its recognition of humanity as a participant in (not an enemy of) ecosystems, the movement is centered on ecology, health, and human rights.

Environmental racism

Environmental racism, ecological racism or ecological apartheid is a form of institutional racism leading to landfills, incinerators, and hazardous waste disposal being disproportionately placed in communities of color. Internationally, it is also associated with extractivism, which places the environmental burdens of mining, oil extraction, and industrial agriculture upon indigenous peoples and poorer nations largely inhabited by people of color.

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Multistage carcinogenesis and the fraction at risk

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