Publication

Covalently attached lipid bilayers on planar waveguides for measuring protein binding to functionalized membranes

Horst Arthur Vogel
1996
Book Chapters

Abstract

A new method was presented to investigate the interactions between membrane receptors and their ligands in an artificial, reconstituted membrane system. Lipid bilayers were anchored via covalently attached thiolipids to TiO2/SiO2 waveguide surfaces to produce mech. stable, long-lasting, and reusable membranes. The coupling scheme was designed to keep the membrane at a distance from the surface, thus maintaining a certain membrane flexibility and allowing for an aq. phase between the surface and bilayer. The method yielded imperfect, covalently bound thiolipid layers which can be converted to lipid bilayers by self-assembly of phospholipids. [on SciFinder (R)]

Official source

https://infoscience.epfl.ch/entities/publication/aa536f18-455d-4830-817d-54df7ab56804

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Horst Arthur Vogel
1996
Book Chapters

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/aa536f18-455d-4830-817d-54df7ab56804

About this result

Related concepts (32)

Cell membrane

The cell membrane (also known as the plasma membrane or cytoplasmic membrane, and historically referred to as the plasmalemma) is a biological membrane that separates and protects the interior of a cell from the outside environment (the extracellular space). The cell membrane consists of a lipid bilayer, made up of two layers of phospholipids with cholesterols (a lipid component) interspersed between them, maintaining appropriate membrane fluidity at various temperatures.

Membrane

A membrane is a selective barrier; it allows some things to pass through but stops others. Such things may be molecules, ions, or other small particles. Membranes can be generally classified into synthetic membranes and biological membranes. Biological membranes include cell membranes (outer coverings of cells or organelles that allow passage of certain constituents); nuclear membranes, which cover a cell nucleus; and tissue membranes, such as mucosae and serosae.

Membrane protein

Membrane proteins are common proteins that are part of, or interact with, biological membranes. Membrane proteins fall into several broad categories depending on their location. Integral membrane proteins are a permanent part of a cell membrane and can either penetrate the membrane (transmembrane) or associate with one or the other side of a membrane (integral monotopic). Peripheral membrane proteins are transiently associated with the cell membrane.