Role of the Glyoxalase System in Astrocyte-Mediated Neuroprotection

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Plasma-activated water (PAW) is an innovative antimicrobial solution with great potential in enhancing food safety, advancing healthcare, and supporting environmental sustainability. This thesis investigates the inactivation mechanisms of \textit{Escherich ...

Tracking hyperpolarized (HP) ¹³C labeling from either [1-¹³C] pyruvate or [1-¹³C] lactate is a useful tool to assess intermediary metabolism in vivo, which has already been translated from preclinical to clinical research. HP [1-¹³C] pyruvate and [1-¹³C] l ...

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Cis-genetic effects are key determinants of transcriptional divergence in discrete tissues and cell types. However, how cis- and trans-effects act across continuous trajectories of cellular differentiation in vivo is poorly understood. Here, we quantify al ...

Communication between the intestine and other organs such as the lungs, brain or bones is mediated by several metabolites, like short-chain fatty acids or bile acids, that relay information about nutritional and microbiota status. Bile acids are endogenous ...

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We derived computationally efficient average response models of different types of cortical neurons, which are subject to external electric fields from Transcranial Magnetic Stimulation. We used 24 reconstructions of pyramidal cells (PC) from layer 2/3, 24 ...

Role of the Glyoxalase System in Astrocyte-Mediated Neuroprotection

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Fundamentals on the mechanisms involved in plasma-activated water decontamination

Tracking Hyperpolarized [1-¹³C] Pyruvate and [1-¹³C] L-Lactate Metabolism in the Healthy and Post-Stroke Mouse Brain

Accessible and highly observable gastrointestinal organoid model systems for studying host-pathogen interactions

Multimodal transcriptomic atlases of mouse spinal cord injury

Deciphering the nature of cell state transitions in single cells using quantitative modeling of temporal dynamics

The dynamic genetic determinants of increased transcriptional divergence in spermatids

Characterization of the gut-bone marrow axis through bile acid signaling

Ru(II)-Arene Complexes of Curcumin and Bisdesmethoxycurcumin Metabolites

Toward universal cell embeddings: integrating single-cell RNA-seq datasets across species with SATURN

Bioengineering functional organoid models across scales

Single-cell epigenomic reconstruction of developmental trajectories from pluripotency in human neural organoid systems

Distinct ultrastructural phenotypes of glial and neuronal alpha-synuclein inclusions in multiple system atrophy

Clinically compliant cryopreservation of differentiated retinal pigment epithelial cells

Heterogeneity and developmental dynamics of mammalian neocortical progenitors

Brain matters: unveiling the distinct contributions of region, age, and sex to glia diversity and CNS function

Comprehensive proteomic analysis of JC polyomavirus-infected human astrocytes and their extracellular vesicles

Bioengineering human mini-intestines with in vivo-like complexity and function

Countering T cell exhaustion and senescence for enhanced adoptive T cell therapies against solid tumors

Molecular reconstruction and simulation of the Neuron-Glia-Vasculature system

Directional sensitivity of cortical neurons towards TMS induced electric fields