Differential roles of the pRb and Arf/p53 pathways in murine naevus and melanoma genesis

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We study integrals of the form integral(Omega) f(d omega(1), ..., d omega(m)), where m >= 1 is a given integer, 1

Forkciphers are a new kind of primitive proposed recently by Andreeva et al. for efficient encryption and authentication of small messages. They fork the middle state of a cipher and encrypt it twice under two smaller independent permutations. Thus, forkci ...

Cutaneous melanoma is one of the most aggressive cancers characterized by a high plasticity, a propensity for metastasis, and drug resistance. Melanomas are composed of phenotypically diverse subpopulations of tumor cells with heterogeneous molecular profi ...

MicroRNA-mediated gene regulation has been implicated in various diseases, including cancer. This study examined the role of microRNAs (miRNAs) during tumorigenesis and malignant progression of pancreatic neuroendocrine tumors (PanNETs) in a genetically en ...

There is currently no approved treatment for Netherton syndrome, which is a severe, genetic skin disease characterized by chronic inflammation and excessive peeling of the skin. Even though the molecular disease mechanism has been assigned to the unopposed ...

Background: Cortical function is dependent on the balance between excitatory and inhibitory influences. In the human motor cortex, surrogates of these interactions can be measured in vivo, non-invasively with double-pulse transcranial magnetic stimulation ...

The common experimental use of B16-F10 melanoma cells focuses on exploring their metastatic potential following intravenous injection into mice. In this study, B16-F10 cells are used to develop a primary tumor model by implanting them directly into the ear ...

By screening a drug library comprising FDA approved compounds, we discovered a potent interaction between the antifungal agent haloprogin and the experimental organometallic drug RAPTA-T, to synergistically induce cancer cell killing. The combination of th ...

Increased density of tumor-associated lymphatic vessels correlates with poor patient survival in melanoma and other cancers, yet lymphatic drainage is essential for initiating an immune response. Here we asked whether and how lymphatic vessel density (LVD) ...

Cancer is the second leading cause of death in the world and melanoma is the deadliest type of skin cancer. Although surgery, radiotherapy and chemotherapy are still standard treatments, the discovery of the role played by the immune system in cancer has a ...

The discovery of cancer-associated alterations has primarily focused on genetic variants. Nonetheless, altered epigenomes contribute to deregulate transcription and promote oncogenic pathways. Here, we designed an algorithmic approach (RESET) to identify a ...

Differential roles of the pRb and Arf/p53 pathways in murine naevus and melanoma genesis

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Calculus of variations: A differential form approach

Cryptanalysis of ForkAES

Cancer cell-derived long pentraxin 3 (PTX3) promotes melanoma migration through a toll-like receptor 4 (TLR4)/NF-kappa B signaling pathway

A set of microRNAs coordinately controls tumorigenesis, invasion, and metastasis

Development of Tissue Kallikrein Inhibitors for the Treatment of Netherton Syndrome

The Effects of Stimulator, Waveform, and Current Direction on Intracortical Inhibition and Facilitation: A TMS Comparison Study

Characterization of a B16-F10 melanoma model locally implanted into the ear pinnae of C57BL/6 mice

Drug Repurposing Approach Identifies a Synergistic Drug Combination of an Antifungal Agent and an Experimental Organometallic Drug for Melanoma Treatment

Lymphatic vessel density is associated with CD8(+) T cell infiltration and immunosuppressive factors in human melanoma

Development of a nano-adjuvant cancer vaccine and its evaluation for melanoma in combination with radiotherapy

Pan-Cancer Landscape of Aberrant DNA Methylation across Human Tumors