Publication

A Computational Pipeline for Personalized Modeling of Neuromodulation in Brain Networks

2024

Abstract

We present an advanced computational pipeline designed to assess the physiological effects of non-invasive brain stimulation (NIBS) using highly personalized, large-scale models of brain network dynamics. Starting from structural magnetic resonance imaging (MRI) data, the pipeline constructs detailed, subject-specific 3D finite element models of the head and brain, and performs personalized dosimetric NIBS exposure assessments using these models. Finally, an embedded, mean field representation of brain network dynamics is used to capture the dynamic response to stimulation. This approach supports multiple neurostimulation modalities, and promises to accelerate the optimization of personalized neurostimulation therapies and the development of advanced, closed-loop stimulation protocols.

Official source

https://infoscience.epfl.ch/entities/publication/a5d96489-1cba-4b64-85c0-a3354c2a462e

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2024

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/a5d96489-1cba-4b64-85c0-a3354c2a462e

About this result

Related concepts (32)

Deep brain stimulation

Deep brain stimulation (DBS) is a neurosurgical procedure involving the placement of a medical device called a neurostimulator, which sends electrical impulses, through implanted electrodes, to specific targets in the brain (the brain nucleus) for the treatment of movement disorders, including Parkinson's disease, essential tremor, dystonia, and other conditions such as obsessive-compulsive disorder (OCD) and epilepsy. While its underlying principles and mechanisms are not fully understood, DBS directly changes brain activity in a controlled manner.

Brain–computer interface

A brain–computer interface (BCI), sometimes called a brain–machine interface (BMI) or smartbrain, is a direct communication pathway between the brain's electrical activity and an external device, most commonly a computer or robotic limb. BCIs are often directed at researching, mapping, assisting, augmenting, or repairing human cognitive or sensory-motor functions. They are often conceptualized as a human–machine interface that skips the intermediary component of the physical movement of body parts, although they also raise the possibility of the erasure of the discreteness of brain and machine.

Neurostimulation

Neurostimulation is the purposeful modulation of the nervous system's activity using invasive (e.g. microelectrodes) or non-invasive means (e.g. transcranial magnetic stimulation or transcranial electric stimulation, tES, such as tDCS or transcranial alternating current stimulation, tACS). Neurostimulation usually refers to the electromagnetic approaches to neuromodulation.

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A Computational Pipeline for Personalized Modeling of Neuromodulation in Brain Networks

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