Publication

Amino acid-based H2S donors: N-thiocarboxyanhydrides that release H2S with innocuous byproducts

Kuljeet Kaur
2021
Journal Articles

Abstract

A library of N-thiocarboxyanhydrides (NTAs) derived from natural amino acids with benign byproducts and controlled H2S-release kinetics is reported. Minimal acute in vitro toxicity was observed in multiple cell lines, while longer-term toxicity in cancer cells was observed, with slow-releasing donors exhibiting the greatest cytotoxic effects.

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