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It is disclosed a hydrogel composition for interfacing between a biomedical device and human skin, comprising: an aqueous dispersant phase, a gelling agent, a water-retention compound selected from a list comprising glycerol, hyaluronic acid, polyethylene glycol, propylene glycol, polyvinyl alcohol, sorbitol, xylitol, maltitol, mannitol, trehalose, urea, triacetin in a concentration between 50% and 80% v/v of the total hydrogel composition, and a cholinergic agonist.