Publication

Estimating the Respective Contributions of Human and Viral Genetic Variation to HIV Control

Jacques Fellay, Istvan Bartha, Paul Jack Mc Laren
2017
Journal Articles

Abstract

We evaluated the fraction of variation in HIV-1 set point viral load attributable to viral or human genetic factors by using joint host/pathogen genetic data from 541 HIV infected individuals. We show that viral genetic diversity explains 29% of the variation in viral load while host factors explain 8.4%. Using a joint model including both host and viral effects, we estimate a total of 30% heritability, indicating that most of the host effects are reflected in viral sequence variation.

Official source

https://infoscience.epfl.ch/entities/publication/a4bdc467-244d-4615-b8c5-44e743cd0a75

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Estimating the Respective Contributions of Human and Viral Genetic Variation to HIV Control

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