Exercise and gait/movement analyses in treatment and diagnosis of Parkinson's Disease

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Amyloid self-assembly of alpha-synuclein (alpha Syn) is linked to the pathogenesis of Parkinson's disease (PD). Type 2 diabetes (T2D) has recently emerged as a risk factor for PD. Cross-interactions between their amyloidogenic proteins may act as molecular ...

Mitochondria play essential metabolic roles and are increasingly understood to interact with other organelles, influencing cellular function and disease. Primary cilia, as sensory and signalling organelles, are crucial for neuronal communication and functi ...

The heterogeneity of protein-rich inclusions and its significance in neurodegeneration is poorly understood. Standard patient-derived iPSC models develop inclusions neither reproducibly nor in a reasonable time frame. Here, we developed screenable iPSC “in ...

The present invention relates to a neuromodulation/neurostimulation system (100) for restoring a motor function of the upper and/or lower limbs and facilitating neurological recovery in a patient (P) with spinal cord injury (SCI) and/or other neurological ...

Background and objectives: In multiple sclerosis (MS), slowly expanding lesions were shown to be associated with worse disability and prognosis. Their timely detection from cross-sectional data at early disease stages could be clinically relevant to inform ...

Phantom boarder (PB) is the sensation that someone uninvited is in the patient's home despite evidence to the contrary. It is mostly reported by patients with neurodegenerative disorders such as Alzheimer's disease, dementia with Lewy bodies or Parkinson's ...

The growing demand for online gait phase (GP) estimation, driven by advancements in exoskeletons and prostheses, has prompted numerous approaches in the literature. Some approaches explicitly use time, while others rely on state variables to estimate the G ...

Background: The timed up and go (TUG) is a test used to assess mobility in older adults and patients with neurological conditions. This study aims to compare brain gray matter (GM) correlates and structural covariance networks associated with the TUG time ...

The aggregation of intracellular tau protein is a major hallmark of Alzheimer's disease (AD). The extent and the stereotypical spread of tau pathology in the AD brain are correlated with cognitive decline during disease progression. Here we present an in-d ...

The objective of this work is the evaluation of how sex, age and the kind of followed treatment affect weight loss, as well as the development of an explanation to assess the evolution of weight loss dynamics in overweight men and women. The methods use in ...

With the recent development of effective gene delivery systems, gene therapy for the central nervous system is finding novel applications. Here, we review existing viral vectors and discuss gene therapy strategies that have been proposed for Parkinson's di ...

Exercise and gait/movement analyses in treatment and diagnosis of Parkinson's Disease

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Multi-Targeting Macrocyclic Peptides as Nanomolar Inhibitors of Self- and Cross-Seeded Amyloid Self-Assembly of α-Synuclein

Mitochondrial control of ciliary gene expression and structure in striatal neurons

Rapid iPSC inclusionopathy models shed light on formation, consequence, and molecular subtype of α-synuclein inclusions

Neuromodulation/neurostimulation system for restoring a motor function and facilitating neurological recovery

Microstructural characterization of multiple sclerosis lesion phenotypes using multiparametric longitudinal analysis

Phantom Boarder Relates to Experimentally‐Induced Presence Hallucinations in Parkinson's Disease

State-Based Versus Time-Based Estimation of the Gait Phase for Hip Exoskeletons in Steady and Transient Walking

Default mode network and the timed up and go in MCI: A structural covariance analysis

Calpain-mediated tau fragmentation is altered in Alzheimer's disease progression

Effects of Age, Sex and Treatment on Weight Loss Dynamics in Overweight People

Parkinson's Disease: Gene Therapies