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Publication

A Palladium-Catalyzed Aminoalkynylation Strategy towards Bicyclic Heterocycles: Synthesis of (±)-Trachelanthamidine

Jérôme Waser, Stefano Nicolai, Cyril Piemontesi
2011
Journal Articles

Abstract

Sweet cyclizations: The synthesis of pyrrolizidines and indolizidines has been achieved. Olefins were subjected to an intramolecular palladium-catalyzed aminoalkynylation with the hypervalent iodine reagent TIPS-EBX. After removal of the protecting group, a two-step cyclization sequence and subsequent reduction led to the natural product (±)-trachelanthamidine (see scheme; TIPS-EBX=triisopropylsilyl ethynylbenziodoxolone).

Official source

https://infoscience.epfl.ch/entities/publication/a3dbe86a-3a44-4e16-97e2-4b223d3466ce

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Jérôme Waser, Stefano Nicolai, Cyril Piemontesi
2011
Journal Articles

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/a3dbe86a-3a44-4e16-97e2-4b223d3466ce

About this result

Related concepts (3)

Product topology

In topology and related areas of mathematics, a product space is the Cartesian product of a family of topological spaces equipped with a natural topology called the product topology. This topology differs from another, perhaps more natural-seeming, topology called the box topology, which can also be given to a product space and which agrees with the product topology when the product is over only finitely many spaces.

Cartesian product

In mathematics, specifically set theory, the Cartesian product of two sets A and B, denoted A × B, is the set of all ordered pairs (a, b) where a is in A and b is in B. In terms of set-builder notation, that is A table can be created by taking the Cartesian product of a set of rows and a set of columns. If the Cartesian product rows × columns is taken, the cells of the table contain ordered pairs of the form (row value, column value).

Direct product

In mathematics, one can often define a direct product of objects already known, giving a new one. This generalizes the Cartesian product of the underlying sets, together with a suitably defined structure on the product set. More abstractly, one talks about the , which formalizes these notions. Examples are the product of sets, groups (described below), rings, and other algebraic structures. The product of topological spaces is another instance. There is also the direct sum – in some areas this is used interchangeably, while in others it is a different concept.

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A Palladium-Catalyzed Aminoalkynylation Strategy towards Bicyclic Heterocycles: Synthesis of (±)-Trachelanthamidine

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