Implantable drug delivery device

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Immune-checkpoint inhibitors (ICI) have revolutionized cancer treatment but are responsible for various immune-related adverse events (irAE). The impact of non-anticancer medications (comedications) on irAE occurrence remains largely unexplored. The object ...

The use of soft and stretchable materials allows the development of adaptive robotic systems and human-machine interfaces that are more natural and comfortable to interact with. One of the application fields that benefits the most from these compliant mate ...

Hydropower plants play a crucial role in the power system facing ambitious renewable energy targets. Due to their inherent controllability, they are well suited to provide flexibility to the grid. However, an increased flexibility provision leads to a prol ...

In the modern age of miniaturisation, Smart Materials, a type of material that reacts mechanically to a certain stimulus, have become an integral part of this revolution. Among these materials, Shape Memory Alloys (SMAs), which have the highest volumetric ...

A compressed air driven generator is proposed, where the pneumatic energy is converted into mechanical energy using two vane-type rotational actuators. The use of a second actuator with a higher displacement in order to produce a thermodynamic expansion al ...

In this paper, we propose an improvement of a dielectric elastomer actuator (DEA) based augmented aorta. The actuator is a multi-layered tubular DEA subject to the internal pressure of the blood. When activated in synchronisation with the heart, the DEA su ...

A haptic device is disclosed comprising at least one fluidic actuator operatively connectable with pumping means; and a plurality of movable members mechanically connected with said at least one fluidic actuator, wherein said movable members can perform a ...

Recent advances in soft actuators have enabled systems that are safer to interact with, better at handling fragile objects, able to produce complex shapes with fewer components. However, being inherently soft differs these actuators from their rigid counte ...

Lumped parameter model and mock circulation loop are two tools commonly used in biomedical research to simulate cardiac system in order to study different assist devices. In this paper, a lumped parameter model is proposed to simulate a circulation loop. T ...

Soft wearable robots could provide support for lower and upper limbs, increase weight lifting ability, decrease energy required for walking and running, and even provide haptic feedback. However, to date most of wearable robots are based on electromagnetic ...

The previously reported gel and polymer actuators require external inputs, such as batteries, circuits, electronic circuits, etc., compared with autonomous motions produced by the living organisms. To realize the spontaneous motions, here, we propose to in ...

The hydraulic design of Francis turbines and pump-turbines is an expensive project-specific engineering effort that typically involves a direct iterative exploration of the design space. An inverse design method for turbomachinery has been previously intro ...

Bioresorbable implantable medical devices show a great potential for applications requiring medical care over well‐defined periods of time. Once their function is fulfilled, such implants naturally degrade and resorb in the body, which eliminates adverse l ...

Adaptive joints are structural joints made of materials with enhanced transduction properties that can vary their stiffness via solid-state actuation (e.g. thermal, mechanical). In this work, stiffness tuning is used to switch the joint between a ‘locked’ ...

A significant number of drugs exhibit narrow therapeutic windows and high inter-individual pharmacokinetic variability. In such cases, Therapeutic Drug Monitoring (TDM) is compulsory in order to optimize the efficacy of the drug while avoiding adverse effe ...

We present a fully edible pneumatic actuator based on gelatin-glycerol material. The actuator is monolithic, fabricated via a molding process, and measures 90 mm in length, 20 mm in width, and 17 mm in thickness. Thanks to the material mechanical character ...

Francis turbines are subject to various types of cavitation flow depending on the operating condition. To enable a smooth integration of the renewable energy sources, hydraulic machines are now increasingly required to extend their operating range, especia ...

Due to the penetration of alternative renewable energies, the stabilization of the electrical power network relies on the off-design operation of turbines and pump-turbines in hydro-power plants. The occurrence of cavitation is however a common phenomenon ...

In this study, a double volute centrifugal pump with relative low efficiency and high vibration is redesigned to improve the efficiency and reduce the unsteady radial forces with the aid of unsteady computational fluid dynamics (CFD) analysis. The concept ...

Soft pneumatic actuators (SPAs) are versatile robotic components enabling diverse and complex soft robot hardware design. However, due to inherent material characteristics exhibited by their primary constitutive material, silicone rubber, they often lack r ...

Implantable drug delivery device

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Comedications Associated with Immune-related Adverse Events From Immune-checkpoint Inhibitors

Additively manufactured stretchable zipping electrostatic actuators

Structural impact of the start-up sequence on Pelton turbines lifetime: Analytical prediction and polynomial optimization

Synthesis of Novel Integrated Actuators Powered by Shape Memory Alloys

A High Efficiency Pneumatic Drive System Using Vane-Type Semi-Rotary Actuators

Design and modelling of a tubular dielectric elastomer actuator with constrained radial displacement as a cardiac assist device

Fluid-actuated haptic device and methods for using thereof

Shape programmable multi-stable polymer actuators

Energy Analysis of a Cardiac Assist Device based on Dielectric Elastomer Actuator through an Equivalent Electrical Circuit

Electrically-Driven Soft Fluidic Actuators Combining Stretchable Pumps With Thin McKibben Muscles

Autonomous oil flow generated by self-oscillating polymer gels

Open-Source Implementation and Validation of a 3D Inverse Design Method for Francis Turbine Runners

Biodegradable Frequency‐Selective Magnesium Radio‐Frequency Microresonators for Transient Biomedical Implants

A vibration control strategy using variable stiffness joints

Microdevice-integrated immunoassays for Point-of-Care Therapeutic Drug Monitoring

Soft Pneumatic Gelatin Actuator for Edible Robotics

Experimental evidence of inter-blade cavitation vortex development in Francis turbines at deep part load condition

URANS Models for the Simulation of Full Load Pressure Surge in Francis Turbines Validated by Particle Image Velocimetry

Computational Fluid Dynamics-Based Pump Redesign to Improve Efficiency and Decrease Unsteady Radial Forces

Design and Analysis of a Soft Pneumatic Actuator with Origami Shell Reinforcement