Publications related to Broad-Spectrum Antiviral Agents Based on Multivalent Inhibitors of Viral Infectivity

Related publications (34)

Stability of influenza A virus in droplets and aerosols is heightened by the presence of commensal respiratory bacteria

Athanasios Nenes, Tamar Kohn, Kalliopi Violaki, Ghislain Gilles Jean-Michel Motos, Aline Laetitia Schaub, Shannon Christa David, Walter Hugentobler, Htet Kyi Wynn, Céline Terrettaz, Laura José Costa Henriques

Aerosol transmission remains a major challenge for control of respiratory viruses, particularly those causing recurrent epidemics, like influenza A virus (IAV). These viruses are rarely expelled alone, but instead are embedded in a consortium of microorgan ...

American Society for Microbiology2024

Inactivation of influenza A virus in expiratory droplets and aerosol particles and the associated physicochemical drivers

Aline Laetitia Schaub

Influenza is an infectious respiratory illness caused by influenza viruses. Every year, it causes up to one billion cases of disease worldwide. Despite its high disease burden, the transmission pathway of influenza remains subject to debate. There is incre ...

EPFL2024

Peptide-based virucidal drugs

Francesca Olgiati

Before the COVID-19 pandemic, viruses were not a major priority for the scientific community. Today, many events have changed the world and the importance of studying viruses, vaccines, and antiviral drugs is fully appreciated. The development of effective ...

EPFL2024

Anti-sars-cov-2 antibodies and use thereof in the treatment of sars-cov-2 infection

Didier Trono, Priscilla Turelli

The disclosure provides antibodies, or antigen-binding fragments thereof, and use thereof in prophylaxis, treatment and/or attenuation of a SARS-CoV-2 virus infection. ...

2024

Country-report pattern corrections of new cases allow accurate 2-week predictions of COVID-19 evolution with the Gompertz model

Daniel Molinuevo Gomez

Accurate short-term predictions of COVID-19 cases with empirical models allow Health Officials to prepare for hospital contingencies in a two–three week window given the delay between case reporting and the admission of patients in a hospital. We investiga ...

Nature Research2024

Stimulus-responsive assembly of nonviral nucleocapsids

Angela Steinauer

Controlled assembly of a protein shell around a viral genome is a key step in the life cycle of many viruses. Here we report a strategy for regulating the co-assembly of nonviral proteins and nucleic acids into highly ordered nucleocapsids in vitro. By fus ...

Nature Portfolio2024

Challenges of COVID-19 Case Forecasting in the US, 2020-2021

Joseph Chadi Benoit Lemaitre, Pan Xu

During the COVID-19 pandemic, forecasting COVID-19 trends to support planning and response was a priority for scientists and decision makers alike. In the United States, COVID-19 forecasting was coordinated by a large group of universities, companies, and ...

Public Library Science2024

Viral Genetic Determinants of Prolonged Respiratory Syncytial Virus Infection Among Infants in a Healthy Term Birth Cohort

Jacques Fellay, Thomas Junier, Zhi Ming Xu, Dylan Lawless

Background. Respiratory syncytial virus (RSV) is associated with acute respiratory infection. We sought to identify RSV variants associated with prolonged infection. ...

OXFORD UNIV PRESS INC2023

Multi-site, Multi-domain Airway Tree Modeling

Jiancheng Yang

Open international challenges are becoming the de facto standard for assessing computer vision and image analysis algorithms. In recent years, new methods have extended the reach of pulmonary airway segmentation that is closer to the limit of image resolut ...

Elsevier2023

Topology Repairing of Disconnected Pulmonary Airways and Vessels: Baselines and a Dataset

Jiancheng Yang

Accurate segmentation of pulmonary airways and vessels is crucial for the diagnosis and treatment of pulmonary diseases. However, current deep learning approaches suffer from disconnectivity issues that hinder their clinical usefulness. To address this cha ...

Springer International Publishing Ag2023

Virtual reality intervention alleviates dyspnoea in patients recovering from COVID-19 pneumonia

Olaf Blanke, Bruno Herbelin, Oliver Alan Kannape, Sylvain Cardin, Sophie Jacqueline Andrée Betka, Jemina Fasola, Florian Lance

Background Immersive virtual reality (iVR)-based digital therapeutics are gaining clinical attention in the field of pain management. Based on known analogies between pain and dyspnoea, we investigated the effects of visual respiratory feedback on persiste ...

European Respiratory Soc Journals Ltd2023

A new chapter of healthy indoor air: antiviral air treatments

Shannon Christa David

Aerosol transmission remains a major challenge for the control of respiratory viruses. To date, prevention strategies include masks, vaccinations, physical distancing, travel restrictions, and lockdowns. Such measures are effective but come with heavy soci ...

Wiley2023

Inactivation mechanisms of influenza A virus under pH conditions encountered in aerosol particles as revealed by whole-virus HDX-MS

Tamar Kohn, Athanasios Nenes, Kalliopi Violaki, Ghislain Gilles Jean-Michel Motos, Giovanni D'Angelo, Aline Laetitia Schaub, Shannon Christa David, Walter Hugentobler, Jonathan Paz Montoya

Multiple respiratory viruses, including influenza A virus (IAV), can be transmitted via expiratory aerosol particles, and aerosol pH was recently identified as a major factor influencing airborne virus infectivity. Indoors, small exhaled aerosols undergo r ...

2023

Roles of Clinical Features and Chest CT in Predicting the Outcomes of Hospitalized Patients with COVID-19 Developing AKI

Ali Falsafi

This research aimed to evaluate the clinical features and computed tomography (CT) scans associated with poor outcomes in COVID-19 patients with acute kidney injury (AKI). A total of 351 COVID-19 patients (100 AKI, 251 non-AKI) hospitalized at Imam Hossein ...

IRANIAN SOC NEPHROLGY2023

Markers of limbic system damage following SARS-CoV-2 infection

Dimitri Nestor Alice Van De Ville, Alessandra Griffa, Idris Guessous, Alexandre Cionca

Alterations of the limbic system may be present in the chronic phase of SARS-CoV-2 infection. Our aim was to study the long-term impact of this disease on limbic system-related behaviour and its associated brain functional connectivity, according to the se ...

OXFORD UNIV PRESS2023

Human personal air pollution clouds in a naturally ventilated office during the COVID-19 pandemic

Dusan Licina, Shen Yang, Maria Viviana Gonzalez Serrano

Personal cloud, termed as the difference in air pollutant concentrations between breathing zone and room sites, represents the bias in approximating personal inhalation exposure that is linked to accuracy of health risk assessment. This study performed a t ...

PERGAMON-ELSEVIER SCIENCE LTD2023

Bacterial colonization in realistic environments: how mechanics impact biofilm formation in the wild and during infection

Tamara Rossy

A variety of physical inputs acts onto bacteria in nature. However, these are most often ignored in the studies of their physiology. There is now increasing evidence indicating that bacteria respond to physical stimuli, including mechanical forces. Yet, qu ...

EPFL2023

Expiratory Aerosol pH is a Driver of the Persistence of Airborne Influenza A Virus

Aline Laetitia Schaub

To mitigate the spread of a viral disease, it is crucial to understand the factors that influence airborne virus transmission. However, the micro-environment to which the virus is exposed in expiratory aerosol particles is highly complex. The relative humi ...

SWISS CHEMICAL SOC2023

Deep learning diagnostic and severity-stratification for interstitial lung diseases and chronic obstructive pulmonary disease in digital lung auscultations and ultrasonography: clinical protocol for an observational case-control study

Mary-Anne Hartley, Jonathan Dönz

BackgroundInterstitial lung diseases (ILD), such as idiopathic pulmonary fibrosis (IPF) and non-specific interstitial pneumonia (NSIP), and chronic obstructive pulmonary disease (COPD) are severe, progressive pulmonary disorders with a poor prognosis. Prom ...

BMC2023

DeepBreath-automated detection of respiratory pathology from lung auscultation in 572 pediatric outpatients across 5 countries

Martin Jaggi, Mary-Anne Hartley, Tatjana Chavdarova, Jonathan Dönz

The interpretation of lung auscultation is highly subjective and relies on non-specific nomenclature. Computer-aided analysis has the potential to better standardize and automate evaluation. We used 35.9 hours of auscultation audio from 572 pediatric outpa ...

NATURE PORTFOLIO2023