Metabolic Networks of Longevity

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Research in biological sciences is in the midst of a true revolution as a result of the emergence and growing impact of a series of new '-omics' disciplines and tools. These include genomics, transcriptomics, proteomics and metabolomics devoted respectivel ...

Microorganisms are essential for life on Earth, performing key roles in numerous biological processes. Their influence extends across a wide spectrum, from human health and ecological balance to advancements in biotechnology and industrial applications. Th ...

Microorganisms are a key component in the chain of life. They are essential for agriculture, produce a large proportion of oxygen, and play a central role in the cycle of elements. Microorganisms are widely used in the production of food and alcoholic beve ...

Automating experimental procedures has resulted in an unprecedented increase in the volume of generated data, which, in turn, has caused an accumulation of unprocessed data. As a result, the need to develop tools to analyze data systematically has been ris ...

The metabolic engineering community relies on computational methods for pathway design to produce important small molecules in microbial hosts. Metabolic network databases are continuously curated and updated with known and novel reactions that expand the ...

Disturbances in the brain's capacity to meet its energy demand increase the risk of synaptic loss, neurodegeneration, and cognitive decline. Nutritional and metabolic interventions that target metabolic pathways combined with diagnostics to identify defici ...

Metabolic "dark matter" describes currently unknown metabolic processes, which form a blind spot in our general understanding of metabolism and slow down the development of biosynthetic cell factories and naturally derived pharmaceuticals. Mapping the dark ...

AMP-activated Protein Kinase (AMPK) is a central regulator of energy homeostasis and a promising drug target for metabolic disorders. It exists as complexes of three subunits, a catalytic alpha, and two regulatory beta and gamma subunits. The regulation of ...

Metabolic reprogramming is critical for tumor initiation and progression. However, the exact impact of specific metabolic changes on cancer progression is poorly understood. Here, we integrate multimodal analyses of primary and metastatic clonally-related ...

SARS-CoV-2 infections display tremendous interindividual variability, ranging from asymptomatic infections to life-threatening disease. Inborn errors of, and autoantibodies directed against, type I interferons (IFNs) account for about 20% of critical COVID ...

Objective The study was undertaken to show the magnitude of interindividual differences in energy expenditure (i.e., heat production) under normal living conditions with the aim of providing physiological evidence to support the advancement of a personaliz ...

The advancements in genome editing techniques over the past years have rekindled interest in rational metabolic engineering strategies. While Metabolic Control Analysis (MCA) is a well-established method for quantifying the effects of metabolic engineering ...

Diauxie, or the sequential consumption of carbohydrates in bacteria such as Escherichia coli, has been hypothesized to be an evolutionary strategy which allows the organism to maximize its instantaneous specific growth-giving the bacterium a competitive ad ...

Motivation: Finding biosynthetic pathways is essential for metabolic engineering of organisms to produce chemicals, biodegradation prediction of pollutants and drugs, and for the elucidation of bioproduction pathways of secondary metabolites. A key step in ...

It was recently demonstrated that nonpersistent radicals can be generated in frozen solutions of metabolites such as pyruvate by irradiation with UV light, enabling radical-free dissolution dynamic nuclear polarization. Although pyruvate is endogenous, the ...

The metabolic capabilities of the species and the local environment shape the microbial interactions in a community either through the exchange of metabolic products or the competition for the resources. Cells are often arranged in close proximity to each ...

Modelling and analysis of biological systems is crucial in order to quantitatively explain and predict their behaviour. The importance of modelling in systems biology becomes even more evident when tackling complex, large systems. Approaches that rely on ...

Overweight and obesity are increasingly common public health issues worldwide, leading to a wide range of diseases from metabolic syndrome to steatohepatitis and cardiovascular diseases. While the increase in the prevalence of obesity is partly attributabl ...

SIRT5 is a member of the sirtuin family of NAD(+)-dependent protein lysine deacylases implicated in a variety of physiological processes. SIRT5 removes negatively charged malonyl, succinyl, and glutaryl groups from lysine residues and thereby regulates mul ...

Nicotinamide adenine dinucleotide (NAD(+)) and its reduced form (NADH) are coenzymes employed in hundreds of metabolic reactions. NAD(+) also serves as a substrate for enzymes such as sirtuins, poly(ADP-ribose) polymerases (PARPs) and ADP-ribosyl cyclases. ...

Metabolic Networks of Longevity

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Development of Machine Learning methods for the kinetic modelling of metabolic networks for biotechnological and biomedical applications

Optimality principles for the analysis of biological processes across scales: From enzyme kinetics to microbiome dynamics

Reconstruction and analysis of genome-scale metabolic networks in single organisms and microbial communities

Modeling, analysis, and design of complex biological networks

Computational tools and resources for designing new pathways to small molecules

Nutritional metabolism and cerebral bioenergetics in Alzheimer's disease and related dementias

Expanding biochemical knowledge and illuminating metabolic dark matter with ATLASx

AMP-activated Protein Kinase (AMPK): New molecular insights and novel downstream targets

Dynamic partitioning of branched-chain amino acids-derived nitrogen supports renal cancer progression

A global effort to dissect the human genetic basis of resistance to SARS-CoV-2 infection

Interindividual variability of human thermoregulation: Toward personalized ergonomics of the indoor thermal environment

Constraint-based metabolic control analysis for rational strain engineering

Emergence of diauxie as an optimal growth strategy under resource allocation constraints in cellular metabolism

NICEpath: Finding metabolic pathways in large networks through atom-conserving substrate-product pairs

Radical-free hyperpolarized MRI using endogenously occurring pyruvate analogues and UV-induced nonpersistent radicals

Spatio-temporal modeling of the crowding conditions and metabolic variability in microbial communities

Modelling the Intracellular Environment under Uncertainty, from Post-translational Modification to Metabolic Networks

Genetic, metabolic, and molecular insights into the diverse outcomes of diet-induced obesity in mouse

Pharmacological and genetic perturbation establish SIRT5 as a promising target in breast cancer

A Method to Monitor the NAD(+) Metabolome-From Mechanistic to Clinical Applications