Publication

Scalable Reverse Engineering of Nonlinear Gene Networks

Dario Floreano
2008
Posters

Abstract

Current advanced molecular biology techniques provide gene expression (mRNA) levels of selected genes of an organism. In such aggregate, the mRNA level of one gene is mediated by the presence of specific proteins and metabolites produced by other genes. Gene Regulatory Networks (GRNs) include such structures, where a node (gene) is linked to others through gene-gene interactions. The developed algorithm is a new state-of-the-art process to infer GRNs, that is to find the gene-gene relationships from experimental mRNA levels. Knowledge of such interactions and so having possibility to act and control genes is important in biotech and pharmaceutical industries.

Official source

https://infoscience.epfl.ch/entities/publication/9edbc181-15a8-4edd-8fdf-f879a2f58ef2

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Dario Floreano
2008
Posters

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/9edbc181-15a8-4edd-8fdf-f879a2f58ef2

About this result

Related concepts (32)

Gene regulatory network

A gene (or genetic) regulatory network (GRN) is a collection of molecular regulators that interact with each other and with other substances in the cell to govern the gene expression levels of mRNA and proteins which, in turn, determine the function of the cell. GRN also play a central role in morphogenesis, the creation of body structures, which in turn is central to evolutionary developmental biology (evo-devo).

Regulation of gene expression

Regulation of gene expression, or gene regulation, includes a wide range of mechanisms that are used by cells to increase or decrease the production of specific gene products (protein or RNA). Sophisticated programs of gene expression are widely observed in biology, for example to trigger developmental pathways, respond to environmental stimuli, or adapt to new food sources. Virtually any step of gene expression can be modulated, from transcriptional initiation, to RNA processing, and to the post-translational modification of a protein.

Gene

In biology, the word gene (from γένος, génos; meaning generation or birth or gender) can have several different meanings. The Mendelian gene is a basic unit of heredity and the molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protein-coding genes and noncoding genes. During gene expression, the DNA is first copied into RNA. The RNA can be directly functional or be the intermediate template for a protein that performs a function.

Related publications (12)

Scalable Reverse Engineering of Nonlinear Gene Networks

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