Publication

Ionic liquids: Solutions for Electrospray Ionisation Mass Spectrometry

2009
Conference Papers

Abstract

Ionic liquids pose challenges and provide solutions for electrospray ionisation mass spectrometry (ESI-MS). Being inherently charged, they are themselves easy to characterise in both positive- and negative-ion mode by ESI-MS, but the challenge arises when using the ionic liquid as a solvent - how does one then identify the solute? Fortunately, an excess of one charged species does not preclude the detection of others, and good data on charged analytes dissolved in ionic liquids can be obtained. In return, ionic liquids can also be used to solve problems in ESI-MS, most notably removing the restriction that only polar solvents can support the electrospray ionisation process.

Official source

https://infoscience.epfl.ch/entities/publication/9e011c36-b40b-4a6a-81d7-33c9647e74e5

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2009
Conference Papers

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/9e011c36-b40b-4a6a-81d7-33c9647e74e5

About this result

Related concepts (24)

Electrospray ionization

Electrospray ionization (ESI) is a technique used in mass spectrometry to produce ions using an electrospray in which a high voltage is applied to a liquid to create an aerosol. It is especially useful in producing ions from macromolecules because it overcomes the propensity of these molecules to fragment when ionized. ESI is different from other ionization processes (e.g. matrix-assisted laser desorption/ionization (MALDI)) since it may produce multiple-charged ions, effectively extending the mass range of the analyser to accommodate the kDa-MDa orders of magnitude observed in proteins and their associated polypeptide fragments.

Liquid chromatography–mass spectrometry

Liquid chromatography–mass spectrometry (LC–MS) is an analytical chemistry technique that combines the physical separation capabilities of liquid chromatography (or HPLC) with the mass analysis capabilities of mass spectrometry (MS). Coupled chromatography - MS systems are popular in chemical analysis because the individual capabilities of each technique are enhanced synergistically. While liquid chromatography separates mixtures with multiple components, mass spectrometry provides spectral information that may help to identify (or confirm the suspected identity of) each separated component.

Ionic liquid

An ionic liquid (IL) is a salt in the liquid state. In some contexts, the term has been restricted to salts whose melting point is below a specific temperature, such as . While ordinary liquids such as water and gasoline are predominantly made of electrically neutral molecules, ionic liquids are largely made of ions. These substances are variously called liquid electrolytes, ionic melts, ionic fluids, fused salts, liquid salts, or ionic glasses. Ionic liquids have many potential applications.

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Ionic liquids: Solutions for Electrospray Ionisation Mass Spectrometry

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