Dietary L-Glu sensing by enteroendocrine cells adjusts food intake via modulating gut PYY/NPF secretion

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Metabolic changes precede malignant histology. However, it remains unclear whether detectable characteristic metabolome exists in esophageal squamous cell carcinoma (ESCC) tissues and biofluids for early diagnosis. Here, we conduct NMR- and MS-based metabo ...

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The present invention relates to variants of the GAIN domain (G-protein-coupled receptor autoproteolysis-inducing domain) of an adhesion G protein-coupled receptor (ADGRG), such as a GAIN domain variant comprising or consisting of the amino acid sequence o ...

Leaf-feeding insects trigger high-amplitude, defense-inducing electrical signals called slow wave potentials (SWPs). These signals are thought to be triggered by the long-distance transport of low molecular mass elicitors termed Ricca's factors. We sought ...

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The Component Process Model is a well-established framework describing an emotion as a dynamic process with five highly interrelated components: cognitive appraisal, expression, motivation, physiology and feeling. Yet, few empirical studies have systematic ...

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Glutamate is a principal neurotransmitter used extensively by the nervous systems of all vertebrate and invertebrate animals. It is primarily an excitatory neurotransmitter that has been implicated in nervous system development, as well as a myriad of brai ...

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PURPOSE: Determine the feasibility of (1) H-[(13) C] MRS in the mouse hypothalamus using a 14.1T magnet. METHODS: We optimized the design of a (1) H-[(13) C] surface coil to maximize the signal-to-noise ratio of (1) H-[(13) C] MRS in the mouse hypothalamus ...

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Recent studies have shown that cannabis may disrupt glutamate (Glu) signaling depressing Glu tone in frequent users. Current evidence have also consistently reported lower Glu-levels in various brain regions, particularly in the medial prefrontal cortex (m ...

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Here, the authors use smFRET to assess the structural dynamics of metabotropic glutamate receptor mGlu2 and show that a positive allosteric modulator or the Gi protein stabilize mGlu2 in the glutamate-induced active state, leading to the full activation of ...

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G protein-coupled receptor (GPCR) signaling occurs in complex spatiotemporal patterns that are difficult to probe using standard pharmacological and genetic approaches. A powerful approach for dissecting GPCRs is to use light-controlled pharmacological age ...

Dietary L-Glu sensing by enteroendocrine cells adjusts food intake via modulating gut PYY/NPF secretion

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Structural investigations of brain and skin tissues in Parkinson's and related diseases, using correlative light and electron microscopy

NMR and MS reveal characteristic metabolome atlas and optimize esophageal squamous cell carcinoma early detection

Structure of tetrameric forms of the serotonin-gated 5-HT3A receptor ion channel

Variants of the gain domain of adhesion g protein-coupled receptors

Ricca's factors as mobile proteinaceous effectors of electrical signaling

Modeling, analysis, and design of complex biological networks

Emotion Recognition in a Multi-Componential Framework: The Role of Physiology

Photoredox-Catalyzed Decarboxylation for the Transfer of Alkynes and Nitriles Using Hypervalent Iodine Reagents

A conditional glutamatergic synaptic vesicle marker for Drosophila

Atomistic simulation of bio-relevant ionic and organic species interacting with rutile - Towards the understanding of apatite formation

Feasibility of in vivo measurement of glucose metabolism in the mouse hypothalamus by (1) H-[(13) C] MRS at 14.1T

The functional characterization of callosal connections

Catalytic amino acid production from biomass-derived intermediates

Cannabis use in early psychosis is associated with reduced glutamate levels in the prefrontal cortex

Nature-inspired Circular-economy Recycling (NaCRe) for Proteins

Understanding the interactions of diruthenium anticancer agents with amino acids

Allosteric modulators enhance agonist efficacy by increasing the residence time of a GPCR in the active state

Neutrophil metabolism in the cancer context

Social isolation stress and chronic glutathione deficiency have a common effect on the glutamine-to-glutamate ratio and myo-inositol concentration in the mouse frontal cortex

Dual optical control and mechanistic insights into photoswitchable group II and III metabotropic glutamate receptors