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Publication

T1 mapping of the mouse brain following fractionated manganese administration using MP2RAGE

Nathalie Just, Mario Gaetano Lepore, Florent Eggenschwiler, Olivier Benoit Thomas Reynaud, Carola Jaquelina del Carmen Romero
2017
Journal Articles

Abstract

With the increasing development of transgenic mouse models of neurodegenerative diseases allowing improved understanding of the underlying mechanisms of these disorders, robust quantitative mapping techniques are also needed in rodents. MP2RAGE has shown great potential for structural imaging in humans at high fields. In the present work, MP2RAGE was successfully implemented at 9.4T and 14.1T. Following fractionated injections of MnCl2, MP2RAGE images were acquired allowing simultaneous depiction and T1 mapping of structures in the mouse brain at both fields. In addition, T1 maps demonstrated significant T1 shortenings in different structures of the mouse brain (p

Official source

https://infoscience.epfl.ch/entities/publication/97a0991a-8680-4f40-9d70-09163397318b

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Nathalie Just, Mario Gaetano Lepore, Florent Eggenschwiler, Olivier Benoit Thomas Reynaud, Carola Jaquelina del Carmen Romero
2017
Journal Articles

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/97a0991a-8680-4f40-9d70-09163397318b

About this result

Related concepts (19)

Pituitary gland

In vertebrate anatomy, the pituitary gland (or hypophysis cerebri) is an endocrine gland. In humans, it is about the size of a chickpea and weighs, on average, . It is a protrusion off the bottom of the hypothalamus at the base of the brain. The hypophysis rests upon the hypophyseal fossa of the sphenoid bone in the center of the middle cranial fossa and is surrounded by a small bony cavity (sella turcica) covered by a dural fold (diaphragma sellae).

Anterior pituitary

A major organ of the endocrine system, the anterior pituitary (also called the adenohypophysis or pars anterior) is the glandular, anterior lobe that together with the posterior lobe (posterior pituitary, or the neurohypophysis) makes up the pituitary gland (hypophysis). The anterior pituitary regulates several physiological processes, including stress, growth, reproduction, and lactation. Proper functioning of the anterior pituitary and of the organs it regulates can often be ascertained via blood tests that measure hormone levels.

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Pituitary adenomas are tumors that occur in the pituitary gland. Most pituitary tumors are benign, approximately 35% are invasive and just 0.1% to 0.2% are carcinomas. Pituitary adenomas represent from 10% to 25% of all intracranial neoplasms and the estimated prevalence rate in the general population is approximately 17%. Non-invasive and non-secreting pituitary adenomas are considered to be benign in the literal as well as the clinical sense; however a recent meta-analysis (Fernández-Balsells, et al.

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T1 mapping of the mouse brain following fractionated manganese administration using MP2RAGE

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