Publication

1H MRS to investigate the hepatic profile of GLUT2-/- mice

2014
Posters

Abstract

We performed 1H MRS at 14.1T in the liver of GLUT2-/- and wild-type (WT) mice. Improved spectral resolution allowed identifying peaks from the lipid resonances, choline containing compounds, taurine and glycogen in WT mice. Performing the same measurements in GLUT2-/- mice revealed a strong contribution from carbohydrates, notably glucose, to the 1H MR liver spectrum. Also a reduced lipid content was detected by 1H MRS in those mice. The characterization of the hepatic profile by 1H MRS in GLUT2-/- mice is of great value to address changes in the main energy fuels in the liver longitudinally.

Official source

https://infoscience.epfl.ch/entities/publication/964b8fb6-b243-4cf6-b3f9-222fe257fb17

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2014
Posters

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/964b8fb6-b243-4cf6-b3f9-222fe257fb17

About this result

Related concepts (32)

Liver disease

Liver disease, or hepatic disease, is any of many diseases of the liver. If long-lasting it is termed chronic liver disease. Although the diseases differ in detail, liver diseases often have features in common. File:Ground glass hepatocytes high mag cropped 2.jpg|Ground glass hepatocytes File:Primary biliary cirrhosis intermed mag much cropping.jpg|Primary biliary cirrhosis File:Buddchiari2.PNG|Budd-chiari syndrome File:Non-alcoholic_fatty_liver_disease1.

Liver

The liver is a major metabolic organ only found in vertebrate animals, which performs many essential biological functions such as detoxification of the organism, and the synthesis of proteins and biochemicals necessary for digestion and growth. In humans, it is located in the right upper quadrant of the abdomen, below the diaphragm and mostly shielded by the lower right rib cage. Its other metabolic roles include carbohydrate metabolism, the production of hormones, conversion and storage of nutrients such as glucose and glycogen, and the decomposition of red blood cells.

Liver cancer

Liver cancer (also known as hepatic cancer, primary hepatic cancer, or primary hepatic malignancy) is cancer that starts in the liver. Liver cancer can be primary (starts in liver) or secondary (meaning cancer which has spread from elsewhere to the liver, known as liver metastasis). Liver metastasis is more common than that which starts in the liver. Liver cancer is increasing globally. Primary liver cancer is globally the sixth-most frequent cancer and the fourth-leading cause of death from cancer.

Related publications (5)

1H MRS to investigate the hepatic profile of GLUT2-/- mice

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